Subhamoy Dasgupta, PhDAssistant Professor
Roswell Park Comprehensive Cancer Center
Buffalo, NY 14263
Topic : Transcriptional control of Tumor Metabolic Adaptations.
Hangout Schedule: May 18th : 9 am EST, 8 am CST, 6 am PST, 6.30pm IST
Dr. Subhamoy Dasgupta joined the faculty of Cell Stress Biology at the Roswell Park Comprehensive Cancer Center in July 2017 as an Assistant Member and Assistant Professor of Oncology. Subho earned his BS in Chemistry and Microbiology from Bangalore University, a MS in Biochemistry from Banaras Hindu University, India and a PhD in Biomedical Sciences from UNT Health Science Center at Fort Worth, Texas. As a graduate student he characterized the functional role of a novel oncogene named C17orf37/MIEN1 in prostate and breast cancer invasion-metastasis (Oncogene, 2009) under the mentorship of Dr. JK Vishwanatha. His doctoral thesis revealed how isoprenylation of MIEN1 protein can regulate its translocation to the plasma membrane and activate signaling events leading to increased invasive phenotype (JBC, 2011; Mol Can, 2015).
Dr. Dasgupta performed postdoctoral fellowship in the laboratory of Dr. Bert W. O'Malley at Baylor College of Medicine at Houston, where he demonstrated that transcriptional coregulator steroid receptor coactivator 2 (SRC-2/NCOA2) regulates metabolic reprogramming to accentuate prostate cancer metastasis (JCI, 2015). As a Susan G. Komen Postdoctoral fellow, he uncovered a novel interplay between a glycolytic enzyme and oncogenic coactivator SRC-3/AIB1 leading to increased proliferation and metastasis of breast tumors.
His laboratory is interested in understanding the role of metabolic adaptations in breast and prostate cancer progression, and elucidating mechanisms that promote therapy resistant aggressive metastatic disease. Dr. Dasgupta’s laboratory is funded by grants from National Cancer Institute (NCI) and Department of Defense (DoD).
- Dasgupta S, Putluri N, Long W, Kaushik AK, Zhang B, Bhowmik SK, Wang J, Stashi E, Brennan CA, Ittmann MM, Mitsiades N, Chinnaiyan AM, Sreekumar A, O’Malley BW. Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis. Journal of Clinical Investigation. 2015 Mar 2;125(3):1174-88. PMID:25664849 PMCID: PMC4362260. [Featured Publication and Highlighted as Scientific Showstopper: http://www.jci.org/posts/259]
- Zhu B, Stashi E, Gates LA, Dasgupta S, Gonzales N, Dean A, York B and O’Malley BW. Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude through REV-ERB Loading. Molecular Cell. 2015 Dec 3;60(5):769-83. PMID:26611104 PMCID:PMC4671835
- Dasgupta S, Lonard DM, and O’Malley BW. Nuclear Receptor Coactivators: Master Regulators of Human Health and Disease. Annual Reviews of Medicine.2014;65:279-92. PMID: 24111892 PMCID: PMC4327818
- Dasgupta S, Cushman I, Kpetemey M, Casey PJ, and Vishwanatha JK. (2011) Prenylated C17ORF37 induces filopodia formation to promote cell migration and metastasis. Journal of Biological Chemistry 22;286(29):25935-46. PMID:21628459
- Dasgupta S, Wasson LM, Rauniyar N, Prokai L, Borejdo J, and Vishwanatha JK. (2009). Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. Oncogene 28:2860-2872. PMID: 19503095 PMCID: PMC2726905