Dr. Suzanne E. Lapi, Ph.D.
Director, Cyclotron Facility; Director, Radiochemistry LaboratoryAssociate Professor, Advanced Imaging Facility, Division of Advanced Medical Imaging Research
University of Alabama Birmingham, AL, USA
Hangout Title: From Isotopes to Images: Radioactive Materials as Tools in Medicine and Basic Science
Hangout Schedule: May 11th: 9 am EST, 8 am CST, 6 am PST, 6.30 am IST
Suzanne E. Lapi, Ph.D. completed her undergraduate studies and Ph.D. at Simon Fraser University in Burnaby, BC, Canada. She went on to complete a postdoctoral appointment at UCSF working with Henry VanBrocklin, PhD on the development of imaging agents for PSMA in prostate cancer before being recruited as a faculty member at Washington University in St. Louis where she ultimately stayed on as a tenured Associate Professor until 2015.
Dr. Lapi is currently an Associate Professor of Radiology and Chemistry and Cyclotron Facility Director at the University of Alabama at Birmingham where she oversees production of PET radionuclides and radiopharmaceuticals for preclinical and clinical trials. Her research interests are in the development and translation of new PET radionuclides and imaging agents. She is very interested in moving imaging agents forward to clinical use and she is currently producing isotopes and radiopharmaceuticals for several clinical trials. In particular, Dr. Lapi has extensive experience in the preclinical and clinical research use of 89Zr antibodies.
Dr. Lapi has over 50 publications and a track record of grants in the area of isotope production, molecular imaging and training of the next generation of radiochemists. She is President of the Radiopharmaceutical Sciences Council of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) and has been a Board member of the Nuclear Division of the American Chemical Society (ACS) for the past 4 years. She is a board member of the International Society of Radiopharmaceutical Sciences (ISRS) and has been active in many projects with the International Atomic Energy Agency (IAEA). She also continues to be a strong advocate of radiopharmaceutical sciences and the training of future radiochemists.
Publications
- 1. Lapi, S., Ruth, T.J., Zyuzin, A., D’Auria, J.M. (2003) Development of an intense 15O radioactive ion beam using low energy protons. Nuclear Instruments and Methods B 204: 444-446
2. Britto, D.T., Ruth, T.J., Lapi, S., Kronzucker. H.J. (2004) Cellular and whole-plant chloride dynamics in barley: Insights into chloride-nitrogen interactions and salinity responses Planta 218: 615-622
3. Sossi, V., Buckley, K., Piccioni, P., Rahmin, A., Camborde, M., Lapi, S., Ruth, T.J. (2005) Printed Sources for Positron Emission Tomography. IEEE Nuclear Science 52: 114-118
4. Guo, B., Liu, W.P., Trinczek, M., Lapi, S., Ames, F., Buckley, K.R., D’Auria, J.M., Jayamanna, K., Ruiz, C., Ruth, T.J. (2006) Production of intense radioactive beams using low energy protons. High energy physics and nuclear physics (Chinese edition) 30: 675-679
5. Trinczek, M., Lapi, S, Guo, B., Ames, F., Buckley, K.R., D’Auria, J.M., Jayamanna, K., Liu, W.P., Ruiz, C., Ruth, T.J. (2006) Production of intense radioactive beams at ISAC using low energy protons. Canadian Journal of Physics 84: 323-333
6. Heath, S.J., Olson, J.A., Buckley, K. R., Lapi, S., Ruth, T.J., Martinez, D.M. (2007) Visualization of the flow of a fiber suspension through a sudden expansion using PET. American Institute of Chemical Engineering Journal 53: 327-334
7. Lapi, S., Ressler, J.J., Cox, M.E., Ruth, T.J., (2006) High-specific activity 186Re-labeled antibodies for radioimmunotherapy. In Technetium, Rhenium and other metals in chemistry and nuclear medicine, U. Mazzi, ed, S.G. Editoriali, Padova, 2006. 593-596
8. Lapi, S.,Wilson, J., McQuarrie, S., Publicover, J., Schueller, M., Schyler, D., Ressler, J.J., Ruth, T.J. (2007) Measurement of production cross-sections of 181-186Re isotopes from proton bombardment of natural tungsten. Applied Radiation and Isotopes 65: 345-349
9. Ferreira, C.L., Lapi. S., Steele, J., Green, D.E., Ruth, T.J., Adam, M.J. (2007) 55Cobalt Complexes with Pendant Carbohydrates as Potential PET Imaging Agents. Applied Radiation and Isotopes 65:1303-1308
10. Ruprecht, G., Vockenhuber, C., Buchmann, L., Woods, R., Ruiz, C., Lapi, S., Bremmerer, D. (2008) Precise measurement of β-decay and EC modifications in low temperature metal hosts. Physics Review C 77: 065502
11. Annett, A. L., Lapi, S., Ruth, T.J., Maldonado, M.T. (2008) The effects of Cu and Fe availability on the growth and Cu:C ratios of marine diatoms. Journal of Limnology and Oceanography 53: 2451-2461
12. Kronenberg, A., Spejewski, E.H., Carter, H.K., Mervin, B., Jost. C., Stracener, D.W., Lapi, S., Bray, T. (2008) Molecular sidebands for refractory elements for ISOL. Nuclear Instruments and Methods B 266: 4252-4256
13. Lapi, S.E., Voller, T., Welch, M.J. (2009) Positron Emission Tomography Imaging of Hypoxia PET Clinics 4: 39-47
14. Lapi, S.E., Wahhnishe, H., Pham, D., Wu., L.Y., Nedrow-Byers, J.R., Liu, T., VanBrocklin, H.F., Berkman, C.E. Jones, E.F. (2009) Assessment of a [18F]-labeled phosphoramidate peptidomimetic as a new PSMA targeted imaging agent for prostate cancer. Journal of Nuclear Medicine, 50:2042-8
15. Lapi, S.E., Ladouceur, K., Ruth, T.J., D’Auria, J.M. (2010) The MoRe project: An alternative route to the production of High Specific Activity 99Mo In Technetium, Rhenium and other metals in chemistry and nuclear medicine, U. Mazzi, ed, S.G. Editoriali, Padova, 2010. 435-436
16. Guo, J., Annett, A. L., Taylor, R. L., Lapi, S., Ruth, T. J. and Maldonado, M. T. (2010), Copper-uptake kinetics of coastal and oceanic diatoms. Journal of Phycology, 46: 1218–1228.
17. Gagnon, K., Jensen, M., Thisgaard, H., Publicover, J., Lapi, S., McQuarrie, S.A., Ruth, T.J. (2010) A new and simple calibration-independent method for measuring the beam energy of a cyclotron. Applied Radiation and Isotopes 69(1):247-53.
18. Ikotun, O., Lapi, S. (2011) The rise of metal radionuclides in medical imaging: copper-64, zirconium-89 and yttrium-86. Future Medicinal Chemistry, 2011 3(5), 599-621
19. Chang, A.J., DeSilva, R., Jain, S., Lears, K., Rogers, B., Lapi, S.E. (2012) 89Zr-Radiolabled Trastuzumab Imaging in Orthotropic and Metastatic Breast Tumors. Pharmaceuticals, 5(1), 79-83
20. Lapi, S.E., Welch, M.J. (2012) A Historical Perspective on the Specific Activity of Radiopharmaceuticals: What have we learned in the 35 years of the ISRC? Nuclear Medicine and Biology 39(5), 601-8
21. Kume, M., Carey, P.C., Gaehle, G., Madrid, E., Voller, T., Margenau, B., Welch, M.J., Lapi, S.E., (2012) A Semi-Automated System for the Routine Production of Copper-64 Applied Radiation and Isotopes 70(8), 1803-6
22. Lin, M., Ranganathan D., Mori, T., Hagooly, A., Rossin, R., Welch, M.J., Lapi, S.E. (2012) Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of 68Ga-DOTATOC radiosynthesis, Applied Radiation and Isotopes 70(10), 2539-44
23. Chang, A.J., DeSilva, R, Lapi, S.E. (2013) Development and Characterization of 89Zr-labeled Panitumumab for ImmunoPET Imaging of the EGF Receptor, Molecular Imaging, 12(1), 17-27
24. Mebrahtu, E., Zheleznyak, A, Hur, M., Lapi, S.E.(2013) Initial characterization of a dually radiolabeled peptide for simultaneous monitoring of protein targets and enzymatic activity Nuclear Medicine and Biology 40(2), 190-6
25. D’Auria, J.M., Keller, R., Ladoucer, L., Lapi, S.E., Ruth, T.J., Schmor, P. (2013) An alternate approach to the production of radioisotopes for nuclear medicine applications Review of Scientific Instruments 84(3), 034705
26. Chang, A.J., Sohn, R., Lu, Z. H., Arbeit, J.A., Lapi, S.E. (2013) Detection of rapalog-mediated therapeutic response in renal cancer xenografts using 64Cu-bevacizumab ImmunoPET PLoS One 8(3):e58949
27. Lin, M., Welch, M.J., Lapi, S.E. (2013) Effects of Chelator Modifications on 68Ga-Labeled [Tyr3]Octreotide Conjugates Molecular Imaging and Biology 15(5), 606-13
28. Aweda, T., Ikotun, O.F., Mastren, T., Cannon, C.L., Wright, B., Youngs, W.J., Cutler, C., Guthrie, J., Lapi, S.E. (2013) The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials Medicinal Chemical Communications 4, 1015-1017
29. Richards, V., Mebrahtu, E., Lapi, S.E. (2013) Cyclotron Production of 99mTc using 100Mo2C targets Nuclear Medicine and Biology 40(7), 939-45
30. Wright, B., Lapi, S.E, (2013) Designing the Magic Bullet? The Advancement of Immuno-PET into Clinical Use Journal of Nuclear Medicine 54:1171-1174
31. Knight, J.C., Wuest, M., Saad, F.A., Wang, M., Chapman, D.W., Jans, H.S., Lapi, S.E., Kariuki, B.M., Amoroso, A.J., Wuest, F. (2013) Synthesis, characterisation and evaluation of a novel copper-64 complex with selective uptake in EMT-6 cells under hypoxic conditions Dalton Trans. 42(33):12005-14
32. Jin, H., Xu, M., Padakanti, P.K., Liu, Y., Lapi, S.E., Tu, Z. (2013) Preclinical Evaluation of the Novel Monoclonal Antibody H6-11 for Prostate Cancer Imaging Molecular Pharmaceutics, 10(10):3655-64
33. Wooten, A.L., Madrid, E., Schweitzer, A.D., Lawrence, L.A., Mebrahtu, E., Lewis, B.C. Lapi, S.E. (2013) Routine Production of 89Zr Using an Automated Module Applied Science 3(3): 593-613
34. Ikotun, O.F., Marquez, B.V., Huang, C., Masuko, K., Daiji, M., Masuko, T., McConathy, J.E., Lapi, S.E. (2013) Imaging the L-type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPET PLoS ONE 8(10):e77476
35. Zheleznyak, A., Ikotun, O.F., Dimitry, J., Frazier, W.A., Lapi, S.E. (2013) Imaging of CD47 Expression in Xenograft and Allograft Tumor Models Molecular Imaging 12(8):525-34.
36. Pen, A., Mastren, T., Peaslee, G.F., Petrasky, K., DeYoung, P.A., Morrissey, D.J., Lapi, S.E. (2014) Design and construction of a water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory Nuclear Instruments and Methods A, 747: 62-68
37. Marquez, B.V., Ikotun, O.F., Parry, J.J., Rogers, B.E., Meares, C.F., Lapi, S.E. (2014) Development of a Radiolabeled Irreversible Peptide Ligand for PET imaging of VEGF Journal of Nuclear Medicine. 55(6):1029-1034
38. Mastren, T., Guthrie, G., Eisenbeis, P., Voller, T., Mebrahtu, E., Robertson, J.D., Lapi, S.E. (2014) Specific Activity Measurement of 64Cu: A Comparison of Methods Applied Radiation and Isotopes 90: 117-121
39. Ikotun, O.F., Marquez, B.V., Fazen, C.H., Kahkoska, A.R., Doyle, R.P., Lapi, S.E. (2014) Investigation a Vitamin B12 Conjugate as PET Imaging Probe. ChemMedChem 9(6):1244-51
40. Foerster, C., Knight, J.C., Wuest, M., Rowasn, B., Lapi, S.E., Amoroso, A., Edwards, P., Wuest, F. (2014) Synthesis, complex stability and small animal PET imaging of a novel 64Cu-labelled cryptand molecule MedChemComm 5, 958-962
41. Marquez, B.M., Ikotun, O.F., Zheleznyak, A., Wright, B., Hari-Raj, A., Pierce, R.A., Lapi, S.E. (2014) Evaluation of 89Zr-Pertuzumab in breast cancer xenografts, Molecular Pharmaceutics;11(11):3988-95
42. Mastren, T., Pen, A., Peaslee, G.F., Wozniak, N., Loveless, S., Essenmacher, S., Sobotka, L.G., Morrissey, D.J., Lapi, S.E. (2014) Feasibility of isotope harvesting at a projectile fragmentation facility: 67Cu Scientific Reports 4:6706
43. Sharma SK, Wuest M, Wang M, Glubrecht D, Andrais B, Lapi S.E., Wuest F. (2014) Immuno-PET of epithelial ovarian cancer: harnessing the potential of CA125 for non-invasive imaging. EJNMMI Research. 4(1):60.
44. Wooten, A.L. Lewis, B.C., Lapi, S.E. (2015) Cross-sections of (p,x) reactions on natural chromium for the production of 52,52m,54Mn radioisotopes Applied Radiation and Isotopes 96; 154-161
45. Richards V.N., Rath N., Lapi S.E. (2015) Production and separation of 186gRe from proton bombardment of 186WC. Nuclear Medicine and Biology 6:530-5
46. Aweda, T., Zhang, S., Mupanomunda, C., Burkemper, J., Seong Heo, G. Bandara, N., Lin, M., Cutler, C.S., Cannon, C.L., Youngs, W.J., Lapi, S.E. (2015) Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer Journal of Labelled Compounds and Radiopharmaceuticals 58(6):234-41
47. Zheleznyak, A., Garbow, J.R., Neeman, M., Lapi, S.E. (2015) Preclinical PET imaging of acute hyperoxia therapy of chronic hypoxia during pregnancy Molecular Imaging 14:366-72.
48. Mastren, T., Marquez, B.V., Sultan, D., Bollinger, E., Eisenbeis, P., Voller, T., Lapi, S.E. (2015) Cyclotron production of high specific activity 55Co and in vivo evaluation of the stability of 55Co metal-chelate-peptide complexes Molecular Imaging 14:11-22
49. Mastren, T., Pen, A., Loveless, S., Marquez, B., Bolliger, E., Marois, B., Hubley, N., Broan, K., Morrissey, D., Peaslee, G., Lapi, S.E. (2015) Harvesting 67Cu from the Collection of a Secondary Beam Cocktail at the National Superconducting Cyclotron Laboratory Analytical Chemistry 87(20)10323-9
50. Burkemper, J.L., Huang, C., Li, A., Yuan, Rich, K., McConathy, J., Lapi, S.E. (2015) Synthesis and Biological Evaluation of (S)-amino-2-methyl-4-[76Br]-bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging Journal of Medicinal Chemistry 58(21)8542-52
51. Bandara, N., Cherkuri, K., Zheleznyak, A., Griffith, D.A., Limberakis, C., Tess, D.A., Chen, J., Waterhouse, R., Lapi, S.E. (2016) Evaluation of 64Cu and 68Ga Radiolabeled Glucagon-Like Peptide-1 Receptor Agonists as PET Tracers for Pancreatic β-cell Imaging Molecular Imaging and Biology 18(1) 90-8
52. Wright, B.D., Whittenberg, J., Desai, A., DiFelice, C., Kenis, P.J.A, Lapi, S.E., Reichert, D. (2016) Microfluidic Preparation of an 89Zr-Labeled Trastuzumab Single Patient Dose Journal of Nuclear Medicine 57 (5) 747-52
53. Lange, S.E.S., Zheleznyak A., Studer, M.,, O’Shannessy D.J., Lapi S.E., Van Tine B.A. (2016) Development of 89Zr-Ontuxizumab for in vivo TEM-1/endosialin PET Applications Oncotarget 7 (11) 13082-92
54. Wooten, A.L., Lewis, B.C., Szatkowski, D.J., Sultan D.H., Abdin, K.I., Voller, T.F., Liu, Y., Lapi, S.E. (2016) Calibration setting numbers for dose calibrators for the PET isotopes (52)Mn, (64)Cu, (76)Br, (86)Y, (89)Zr, (124)I.Appl Radiat Isot 113:89-95
55. Gordon L, Lapi SE, Anderson C, Schwarz SW; SNMMI Committee on Women in Nuclear Medicine.(2016) Working Together to Advance Women in Nuclear Medicine. J Nucl Med. 2016 Sep;57(9):14N
56. Graaf MD, Marquez BV, Yeh NH, Lapi SE, Moeller KD.(2016) New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF-v107 Binding as Proof of Concept. ACS Chem Biol. (10):2829-2837.
57. Nie X, Randolph GJ, Elvington A, Bandara N, Zheleznyak A, Gropler RJ, Woodard PK, Lapi SE. (2016) Imaging of Hypoxia in Mouse Atherosclerotic Plaques with (64)Cu-ATSM. Nucl Med Biol. 2016 Sep;43(9):534-42.
58. Jin, H., Yang, H., Zhang, Y.,Zhange, X., Rosenberg, A.J., Liu, Y., Lapi, S.E., Tu, Z. (2016) A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury. J Nuci Cardiol. 2016 Feb 2.
59. Laforest, R., Lapi, S.E., Oyama, R., Bose, R.,Tabchy, A., Marquez-Nostra, B.V., Burkemper, J., Wright, B.D., Frye, J., Frye, S. Siegel, B.A., Dehdashti, F. (2016) [89Zr]Trastuzumab: Evaluation of Radiation Dosimetry, Safety, and Optimal Imaging Parameters in Women with HER2-Positive Breast Cancer. Mol Imaging and Biology. 18(6):952-959. 60. Nie X., Laforest R., Elvington A., Randolph GJ., Zheng J., Voller T., Abendschein DR., Lapi SE., Woodard PK.(2016) PET/MR imaging of hypoxic atherosclerosis using 64Cu-ATSM in a rabbit model. J Nucl Med. 2016 Jul 7. pii: jnumed.116.172544.
61. Burkemper JL, Aweda,TA, Rosenberg AJ, Lunderberg DL, Peaslee GF, Lapi SE, (2017) Radiosynthesis and biological distribution of [18F]-labeled perfluorinated alkyl substances Environ. Sci. Technol. Lett. DOI:10.1021/acs.estlett.7b00042
62. Wooten AL, Aweda TA, Lewis BC, Gross RB, Lapi SE. (2017) Biodistribution and PET Imaging of pharmacokinetics of manganese in mice using Manganese-52. PLoS One. 2017 Mar; 12(3):e0174351.doi:10.137
