Researchers have found additional ways to target the molecular processes involved in activating a certain protein complex to potentially develop new therapies for a tumor-causing disorder.These findings are being published in the journal Nature Metabolism.
"Tuberous sclerosis complex, or TSC, is a genetic disorder that causes tumors to form in many different organs including the brain and affects as many as 50,000 people in the U.S. yearly," says co-corresponding and leading author of the paper. "TSC can also affect the brain by causing seizures and autism, among other issues, in newborns and adults. In this condition, the mutations in the genes called Tsc1 or Tsc2 lead to loss of their tumor suppressing functions, which in turn, results in the hyper activation of mTORC1 and its abnormal function, responsible for the multiple symptoms of TSC."
Known as a "master regulator" of cells, mTORC1 is involved in causing the activity of most cell growth; however, it does not promote autophagy -- a regulation method when a cell basically eats itself and an efficient way for fuel generation inside cells.
In this research, scientists saw higher autophagy activity in cells without Tsc1; they then created a "double knockout" animal model -- a model without both Tsc1 and an essential autophagy protein, FIP200, present in the developing nervous system and in adult neural stem cells.
"Using this unique model, we uncovered the essential functions of autophagy as a way to keep mTORC1 activity high and to show the abnormal development of neural stem cells without Tsc1," the lead adds.
Researchers looked at the molecular and metabolic mechanisms of autophagy involved in maintaining high mTORC1 activity and found that it was needed to activate the energy storage, namely lipid droplets in the cells without Tsc.
"The breakdown of lipid droplets by autophagy supplied fatty acid as an energy source to sustain energy production in Tsc1-deficient neural stem cells," the lead says. "We also used pharmacological methods to target autophagy and block fatty acids used to treat defects, mimicking human TSC symptoms in these models."
The other co-corresponding author on the study says these results are key in expanding knowledge of the formation of this disease and how it can be targeted at the molecular level.
https://www.nature.com/articles/s42255-019-0137-5
Autophagy supplies lipid to TSC mutated brain tumors!
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