Tiny structures in our cells, called centrioles, control both cell division and motility. The number of these structures is highly monitored, with deviations causing infertility, microcephaly and accelerating cancer.
But how do mother cells know they provide the right number of centrioles to their daughters? They do it by copying those structures only once, so that each daughter inherits one of the copies. A research team uncovered the mechanism by which the mother copies only once before it distributes it to the two daughters. This study is now published in the scientific journal Current Biology.
While much is known about the regulation of the duplication of the genetic material, it was a mystery how centrioles are copied only once. The team tackled this question by focusing on the key molecular trigger of centriole formation, a protein called PLK4, which they identified recently. "We found that the trigger only works just before centrioles are made. Something in the cell was inhibiting the trigger at other time points, ensuring the right copy number of centrioles was formed at the right time", says co-first author of this study.
The research team set out to investigate what was inhibiting this trigger protein at other time points. "We discovered that a key protein complex that sets the cell division clock, CDK1, inhibits PLK4 activity by kidnapping its partner (STIL). In consequence, PLK4 can only start forming centrioles at a particular time of the cell cycle, when CDK1 is not there", explains the author. The centriole formation machinery is thus regulated by the cell cycle clock, ensuring daughters look like their mothers.
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