By far the most important process in cell development is how cells divide and then enlarge in order to multiply. A research team has now discovered that bundled fibers of actin within a cell nucleus play an important part in how they enlarge after division. Fibers of the structural protein actin stabilize the outer form of the cell and transport substances into a cell. The mechanisms that influence the growth of the cell nucleus after division were less well known by scientists. The researchers have published their results in the journal 'EMBO reports'.
After dividing, cell nuclei have to grow in order to reorganize and unpack the genetic information in chromatin, the basic genetic material, and so process and read it. With this work the scientists show that bundled fibers of actin - which are normally responsible for exercising force - work within the cell to expand the nucleus. Using a video microscope the researchers have measured in living cells how cell nuclei enlarge immediately after division. In order to observe the fibers of actin and skeletal structures in the cell nucleus, they also used a high-resolution super-resolution microscope.
The authors identify non‐muscle α‐actinin 4 (ACTN4) as a critical regulator to facilitate F‐actin reorganization and bundling during postmitotic nuclear expansion. ACTN4 binds to nuclear actin filament structures, and ACTN4 clusters associate with nuclear F‐actin in a highly dynamic fashion. ACTN4 but not ACTN1 is required for proper postmitotic nuclear volume expansion, mediated by its actin‐binding domain.
In the future the team want to clarify whether mechanical forces work within the cell nucleus to re-organize them to sort the genetic information. If so, this process could for example be disrupted or changed in tumor cells or play a part in stem cells.
https://www.embopress.org/doi/full/10.15252/embr.202050758
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fpostmitotic-expansion&filter=22
How nuclei enlarge after cell division
- 820 views
- Added
Edited
Latest News
Complete vascularization of…
By newseditor
Posted 28 Mar
Immune cells identified as…
By newseditor
Posted 28 Mar
TB blood test which could d…
By newseditor
Posted 27 Mar
Propionate supplementation…
By newseditor
Posted 27 Mar
Role of human Kallistatin i…
By newseditor
Posted 26 Mar
Other Top Stories
How mechanical forces nudge tumors toward malignancy
Read more
How cancer evades the immune system
Read more
Genes that drive ovarian cancer identified!
Read more
Neural Differentiation Defect from Loss of a Single Gene Fuels Dead…
Read more
How a protein mutation leads to colorectal cancer
Read more
Protocols
Spatial proteomics in neuro…
By newseditor
Posted 28 Mar
All-optical presynaptic pla…
By newseditor
Posted 23 Mar
Epigenomic tomography for p…
By newseditor
Posted 20 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Publications
A microfluidic platform int…
By newseditor
Posted 28 Mar
Salmonella manipulates macr…
By newseditor
Posted 28 Mar
BHLHE40/41 regulate microgl…
By newseditor
Posted 28 Mar
Balancing neuronal activity…
By newseditor
Posted 28 Mar
OSBP-mediated PI(4)P-choles…
By newseditor
Posted 28 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar