Fibroblast growth factors (fgfs) are widely believed to activate their receptors by mediating receptor dimerization.
Researchers show, however, that the FGF receptors form dimers in the absence of ligand, and that these unliganded dimers are phosphorylated.
Authors further show that ligand binding triggers structural changes in the FGFR dimers, which increase FGFR phosphorylation.
The observed effects due to the ligands fgf1 and fgf2 are very different. The fgf2-bound dimer structure ensures the smallest separation between the transmembrane (TM) domains and the highest possible phosphorylation, a conclusion that is supported by a strong correlation between TM helix separation in the dimer and kinase phosphorylation.
The pathogenic A391E mutation in FGFR3 TM domain emulates the action of fgf2, trapping the FGFR3 dimer in its most active state.
http://www.nature.com/ncomms/2016/160104/ncomms10262/full/ncomms10262.html
Researchers show, however, that the FGF receptors form dimers in the absence of ligand, and that these unliganded dimers are phosphorylated.
Authors further show that ligand binding triggers structural changes in the FGFR dimers, which increase FGFR phosphorylation.
The observed effects due to the ligands fgf1 and fgf2 are very different. The fgf2-bound dimer structure ensures the smallest separation between the transmembrane (TM) domains and the highest possible phosphorylation, a conclusion that is supported by a strong correlation between TM helix separation in the dimer and kinase phosphorylation.
The pathogenic A391E mutation in FGFR3 TM domain emulates the action of fgf2, trapping the FGFR3 dimer in its most active state.
http://www.nature.com/ncomms/2016/160104/ncomms10262/full/ncomms10262.html
Edited
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