Automated liquid handling (ALH) systems efficiently deposit small volumes of liquid using multiple pipette heads simultaneously. Despite their widespread use in academic and industrial laboratories, most existing ALH systems are simply robots that perform the human pipetting movement, and a growing number of applications require fluid manipulation beyond what is currently possible.
To address this need, the authors developed the pixelated chemical display (PCD)—a versatile liquid handling system based on open-space microfluidics. The researchers used 3D printing to fabricate PCDs that could simultaneously project 144 pixels—independent reagent streams—onto surfaces, providing very stable and regular flow patterns.
The streams could be co-localized above a surface and reconfigured over time with precise spatiotemporal control.
The authors used PCDs to deposit a precise silver pattern on thin plastic film. Unlike previously developed open-space microfluidic devices, PCDs are massively parallel, can be scaled to any size, and can operate over dry surfaces, not just immersed surfaces.
According to the authors, PCDs are compatible with a wide range of solvents and acids and may have broad applications in biology, chemistry, and materials science.
https://www.pnas.org/content/118/2/e2019248118
Pixelated chemical displays offer versatile liquid handling
- 1,130 views
- Added
Edited
Latest News
Complete vascularization of…
By newseditor
Posted 28 Mar
Immune cells identified as…
By newseditor
Posted 28 Mar
TB blood test which could d…
By newseditor
Posted 27 Mar
Propionate supplementation…
By newseditor
Posted 27 Mar
Role of human Kallistatin i…
By newseditor
Posted 26 Mar
Other Top Stories
First successful treatment of mycobacterial lung infection with bac…
Read more
Biomaterial improves islet transplants for treatment of type 1 diab…
Read more
How deep brain stimulation treats Parkinson's disease symptoms
Read more
Plasma membrane phospholipid plays a key role in epithelial cell ad…
Read more
Stopping nervous system tumor growth in mice with an epilepsy drug
Read more
Protocols
Spatial proteomics in neuro…
By newseditor
Posted 28 Mar
All-optical presynaptic pla…
By newseditor
Posted 23 Mar
Epigenomic tomography for p…
By newseditor
Posted 20 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Publications
A microfluidic platform int…
By newseditor
Posted 28 Mar
Salmonella manipulates macr…
By newseditor
Posted 28 Mar
BHLHE40/41 regulate microgl…
By newseditor
Posted 28 Mar
Balancing neuronal activity…
By newseditor
Posted 28 Mar
OSBP-mediated PI(4)P-choles…
By newseditor
Posted 28 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar