Cell surface components such as lipids and proteins must be spatially and temporally organized for the execution of several functions, including receptor signaling and vesicular trafficking.
To investigate the role of active processes in cell surface organization, researchers in the journal PNAS used a reconstituted in vitro system consisting of a lipid bilayer, membrane-associated actin-binding components, actin filaments, and myosin motors.
The authors found that the active mechanics of actomyosin complexes, which are made up of actin filaments and myosin motors, can lead to the clustering of membrane components and regulate the local composition of the cell surface.
By systematically changing actin and myosin concentrations and actin filament length, the authors revealed distinct states of actomyosin organization at the membrane surface after ATP consumption. The ATP-dependent actin and myosin dynamics produced transient accumulations of actin-binding membrane molecules, similar to that seen in living cells.
The results suggest that active actomyosin processes can affect the organization of membrane proteins and drive local membrane composition. According to the authors, the actomyosin-driven organization of cell membrane components may have implications for cell signaling.
http://www.pnas.org/content/early/2016/02/24/1514030113
Regulation of cell surface composition
- 1,308 views
- Added
Edited
Latest News
Brain hormone regulate both…
By newseditor
Posted 17 Mar
Blocking long non-coding RN…
By newseditor
Posted 17 Mar
Artificial intelligence and…
By newseditor
Posted 17 Mar
Blood-brain barrier protein…
By newseditor
Posted 17 Mar
Preventing heart attacks an…
By newseditor
Posted 17 Mar
Other Top Stories
8 weeks of meditation studies can make your brain quicker
Read more
Decreased performance under pressure!
Read more
What's the cost of self-control?
Read more
Exercise hormone is a key regulator of cognitive function
Read more
New reward circuitry discovered!
Read more
Protocols
Integration of Kupffer cell…
By newseditor
Posted 18 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Profiling native pulmonary…
By newseditor
Posted 08 Mar
Neuromuscular organoids mod…
By newseditor
Posted 06 Mar
Publications
Synaptopathy: presynaptic c…
By newseditor
Posted 18 Mar
Allergic Rhinitis
By newseditor
Posted 18 Mar
ALK upregulates POSTN and W…
By newseditor
Posted 18 Mar
PRODH safeguards human naiv…
By newseditor
Posted 18 Mar
Secretin-dependent signals…
By newseditor
Posted 17 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar