While long-term memory (LTM) is known to be encoded in specific neural cells, engram neurons, it has been unclear how these engram neurons are formed during training. In Drosophila, aversive olfactory LTM is formed by repetitive training trials with rest intervals between training trial, spaced training.
Drosophila can form Long-term memory (LTM) by repetitive training trials with rest intervals. In the neurons to which information is input, MAPK activates transcription factor CREB by training with an interval, and expresses c-fos. c-Fos is also a transcription factor, which is activated by MAPK and expresses CREB.
By repeating training, it became clear that a transcription cycle such as c-fos expressing CREB and CREB expressing c-fos was formed. Engram cells with high expression level of CREB were formed. In this way, it was revealed that neuronal cells with high expression of CREB were born, and this cell became engram cells. This result is expected not only to elucidate the mechanism of improving the effect of learning, establishment of memory by efficient learning, but also to be useful for the treatment of memory impairment.
By repetitive learning at intervals, MAPK is activated in the nerve cells to which repetitive information is input, so that a transcription cycle of CREB and c-fos is formed. In the nerve cells in which the transcription cycle is formed, the amount of CREB increases and it becomes an engram cell in which long-term memory is formed. Blocking or activating c-fos-positive engram neurons inhibits memory recall or induces memory-associated behaviors.
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31768-6?
Transcriptional cycling establishes long-term memory encoding engram neurons
- 1,533 views
- Added
Edited
Latest News
Metabolic rewiring promotes…
By newseditor
Posted 18 Apr
A drug to prevent flu-induc…
By newseditor
Posted 18 Apr
New origin of deep brain waves
By newseditor
Posted 17 Apr
Starving cells hijack prote…
By newseditor
Posted 17 Apr
Miniature battery-free epid…
By newseditor
Posted 17 Apr
Other Top Stories
How brain uses bodily signals to regulate fear
Read more
Separating fact from fiction for "anti-aging" diets
Read more
The link between vitamin D and inflammation
Read more
Chronic stress and depression related protein crystallized!
Read more
Thousands of novel brain-expressed gene isoforms identified!
Read more
Protocols
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Modular dual-color BiAD sen…
By newseditor
Posted 31 Mar
Publications
How does the microbiota con…
By newseditor
Posted 18 Apr
The integrated stress respo…
By newseditor
Posted 18 Apr
The immunobiology of herpes…
By newseditor
Posted 17 Apr
Circulating microbiome DNA…
By newseditor
Posted 17 Apr
Spindle oscillations in com…
By newseditor
Posted 17 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar