Prostate cancer is one of the most common cancers among men. Patients are determined to have prostate cancer primarily based on PSA, a cancer factor in blood. However, as diagnostic accuracy is as low as 30%, a considerable number of patients undergo additional invasive biopsy and thus suffer from resultant side effects, such as bleeding and pains.
A collaborative research team developed a technique for diagnosing prostate cancer from urine within only twenty minutes with almost 100% accuracy. The research team developed this technique by introducing a smart AI analysis method to an electrical-signal-based ultrasensitive biosensor.
As a noninvasive method, a diagnostic test utilizing urine is convenient for patients and does not need invasive biopsy, thereby diagnosing cancer without side effects. However, as the concentration of cancer factors is low in urine, a urine-based biosensor has been utilized for classifying risk groups rather than for precise diagnosis thus far.
The team has been working toward developing a technique for diagnosing disease from urine by utilizing the electrical-signal-based ultrasensitive biosensor. An approach utilizing a single cancer factor associated with a cancer diagnosis was limited in increasing the diagnosis accuracy to over 90%. However, to overcome this limitation, the team simultaneously utilized different kinds of cancer factors instead of using only one to enhance the diagnostic accuracy innovatively.
The team developed an ultrasensitive semiconductor sensor system capable of simultaneously measuring trace amounts of selected four cancer factors in urine for diagnosing prostate cancer. They trained AI by using the correlation between the four cancer factors, which were obtained from the developed sensor. The trained AI algorithm was then used to identify those with prostate cancer by analyzing complex patterns of the detected signals. The diagnosis of prostate cancer by utilizing the AI analysis successfully detected 76 urinary samples with almost 100 percent accuracy.
"For patients who need surgery and/or treatments, cancer will be diagnosed with high accuracy by utilizing urine to minimize unnecessary biopsy and treatments, which can dramatically reduce medical costs and medical staff's fatigue," the senior author said.
https://pubs.acs.org/doi/10.1021/acsnano.0c06946
A urine test with artificial intelligence to precisely diagnose prostate cancer
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