Amino acids in diet could be key to starving cancer

Amino acids in diet could be key to starving cancer


Cutting out certain amino acids -- the building blocks of proteins -- from the diet of mice slows tumor growth and prolongs survival, according to new research* published in Nature.

Researchers found that removing two non-essential amino acids -- serine and glycine -- from the diet of mice slowed the development of lymphoma and intestinal cancer.

The researchers also found that the special diet made some cancer cells more susceptible to chemicals in cells called reactive oxygen species.

Chemotherapy and radiotherapy boost levels of these chemicals in the cells, so this research suggests a specially formulated diet could make conventional cancer treatments more effective.

The next stage would be to set up clinical trials with cancer patients to assess the feasibility and safety of such a treatment.

Author said: "Our findings suggest that restricting specific amino acids through a controlled diet plan could be an additional part of treatment for some cancer patients in future, helping to make other treatments more effective.

The study co-author said: "This kind of restricted diet would be a short term measure and must be carefully controlled and monitored by doctors for safety. Our diet is complex and protein -- the main source of all amino acids - is vital for our health and well-being. This means that patients cannot safely cut out these specific amino acids simply by following some form of home-made diet."

Amino acids are the building blocks that cells need to make proteins. While healthy cells are able to make sufficient serine and glycine, cancer cells are much more dependent on getting these vital amino acids from the diet.

However, the study also found that the diet was less effective in tumors with an activated Kras gene, such as most pancreatic cancer, because the faulty gene boosted the ability of the cancer cells to make their own serine and glycine. This could help to select which tumors could be best targeted by diet therapy.

http://www.cancerresearchuk.org/about-us/cancer-news/press-release/2017-04-19-amino-acids-in-diet-could-be-key-to-starving-cancer

http://www.nature.com/nature/journal/v544/n7650/full/nature22056.html

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