A new study led by scientists describes an unexpected role for proteins involved with our daily "circadian" clocks in influencing cancer growth.
The research, published in the journal Molecular Cell, suggests that disruptions in circadian rhythms might leave levels of an important cancer-linked protein, called cMYC, unchecked.
There is growing evidence that shift work and frequent jet lag can raise a person's risk of cancer, suggesting a link between daily rhythms and cell growth.
The researchers focused on proteins called cryptochromes, which evolved from bacterial proteins that sense light and repair DNA damage caused by sunlight. In humans, these proteins, called CRY1 and CRY2, regulate our circadian clocks, which influence what times of day we become tired, hungry and much more.
Using cells from mouse models, the researchers demonstrated that deleting the gene that expresses CRY2 reduced the cells' ability to degrade a protein called cMYC. Without CRY2 keeping cMYC at normal levels, the researchers saw increased cell proliferation--similar to the abnormal growth seen in cancers.
Further studies of protein structures suggested that CRY2 is a key player in a process to "mark" cMYC for degradation. The researchers said it is significant that this process occurs after gene transcription--once the proteins are already produced--rather than during transcription, as in many other cryptochrome functions.
The researchers say more studies are needed to confirm this connection between circadian clocks and cancer in human tissues.
http://www.scripps.edu/newsandviews/e_20161121/lamia.html
http://www.cell.com/molecular-cell/abstract/S1097-2765(16)30635-9
How circadian 'clock' may influence cancer pathway
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