Metastatic prostate cancer is a fatal disease with few therapeutic options. Although mutationally activated kinases have been successful therapeutic targets for multiple types of cancer, genetic aberrations of kinases are rare in prostate cancer. However, evidence suggests that nonmutated kinases play a role in the development of metastasis.
Scientists developed an in vivo screen to identify wild-type kinases that can drive prostate cancer metastasis. Using genomic, transcriptomic, and phosphoproteomic databases, the authors studied 125 candidate kinases.
Kinases were overexpressed in a mouse prostate cell line and injected intravenously into immunodeficient mice. Twenty of these kinases caused metastases to develop in mouse lungs.
To determine which kinases are capable of driving metastasis in human cells, all 20 kinases were expressed in a nonmalignant human prostate cell line and separately injected into immunodeficient mice.
Five kinases, including MERTK, NTRK2, and all three RAF family members, drove the formation of bone and visceral metastases in mice. Histological analysis of tissue from human prostate cancer patients showed enhanced expression of these kinases in metastasis samples.
The results suggest that wild-type kinases may be potential therapeutic targets for metastatic prostate cancer, according to the authors.
http://www.pnas.org/content/early/2015/11/25/1521674112
Edited
Latest News
Complete vascularization of…
By newseditor
Posted 28 Mar
Immune cells identified as…
By newseditor
Posted 28 Mar
TB blood test which could d…
By newseditor
Posted 27 Mar
Propionate supplementation…
By newseditor
Posted 27 Mar
Role of human Kallistatin i…
By newseditor
Posted 26 Mar
Other Top Stories
First successful treatment of mycobacterial lung infection with bac…
Read more
Biomaterial improves islet transplants for treatment of type 1 diab…
Read more
How deep brain stimulation treats Parkinson's disease symptoms
Read more
Plasma membrane phospholipid plays a key role in epithelial cell ad…
Read more
Stopping nervous system tumor growth in mice with an epilepsy drug
Read more
Protocols
Spatial proteomics in neuro…
By newseditor
Posted 28 Mar
All-optical presynaptic pla…
By newseditor
Posted 23 Mar
Epigenomic tomography for p…
By newseditor
Posted 20 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Publications
A microfluidic platform int…
By newseditor
Posted 28 Mar
Salmonella manipulates macr…
By newseditor
Posted 28 Mar
BHLHE40/41 regulate microgl…
By newseditor
Posted 28 Mar
Balancing neuronal activity…
By newseditor
Posted 28 Mar
OSBP-mediated PI(4)P-choles…
By newseditor
Posted 28 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar