In a study published in Nature Cancer, researchers demonstrated that NR2F2 is an essential regulator of malignant tumor state by controlling cancer stem cell and tumor maintenance in mouse and human cancers.

The researchers used a combination of state-of-the-art genetic models to assess the role of NR2F2 in mouse and human skin cancer. The authors discovered that NR2F2 is expressed in malignant cancers. Inactivation of NR2F2 blocks the progression of benign to malignant tumors and represses essential tumor functions, leading to tumor regression.

“It was very exciting to observe that genetic or pharmacological inhibition of NR2F2 can cause tumor regression or prevent the progression to invasive malignant tumor states responsible for metastasis” comments the first author of this study.

By performing a detailed histological and molecular characterization of the tumor states following NR2F2 genetic gain and loss of functions studies during tumor progression, the authors unravel the molecular mechanisms by which NR2F2 regulates malignant tumor progression, and tumor growth. NR2F2 promotes tumor cell proliferation, and invasive features, while repressing cell death, tumor differentiation and immune cell infiltration of the tumor.

“One of the most remarkable findings of this study is the demonstration that inactivation of NR2F2 promotes tumor differentiation, leading to tumor regression.  Despite the spectacular efficacity of pro-differentiation therapy for the treatment of pro-myelomonocytic leukemia, very few pro-differentiation therapies are currently used to treat solid cancers. The development of NR2F2 inhibitors should keep in check many essential cancer functions and is thus a very promising strategy for the development of novel anticancer therapy,”, comments the senior author of this study.

https://www.nature.com/articles/s43018-021-00287-5