Tcells protect the body against foreign threats and new enties developed within the body. Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells.
Scientists show in the jpurnal Cell that glucose consumption by tumors metabolically restricts T cells, leading to their dampened function, thereby allowing tumor progression.
Authors show that enhancing glycolysis in a tumor model is sufficient to override the protective ability of T cells to control tumor growth. They also show that checkpoint blockade antibodies which are used clinically, restore glucose in tumor microenvironment, permitting T cell glycolysis and IFN-γ production.
These results establish that tumor-imposed metabolic restrictions can mediate T cell hyporesponsiveness during cancer.