Neem extract shows promise in treating pancreatic cancer

Neem extract shows promise in treating pancreatic cancer

Pancreatic cancer has the highest mortality rate of all cancers with 94% of patients dying within five years of diagnosis. The cancer grows quickly and there are currently no effective treatments available, underscoring the importance of finding new therapies.

A natural extract derived from India's neem tree could potentially be used to treat pancreatic cancer, according to a new study in the journal Scientific Reports.

A compound found in neem leaves, against pancreatic cancer in cell lines and mice. The results revealed that nimbolide can stop pancreatic cancer's growth and metastasis without harming normal, healthy cells.

In the study, Lakshmanaswamy and his lab observed that nimbolide was able to reduce the migration and invasion capabilities of pancreatic cancer cells by 70 percent; meaning the cancerous cells did not become aggressive and spread. And that's promising, the researchers say. In humans, this migration and invasion -- or metastasis -- of pancreatic cancer to other regions of the body is the chief cause of mortality.

Nimbolide treatments also induced cancer cell death, causing the size and number of pancreatic cancer cell colonies to drop by 80 percent. Nimbolide did not harm healthy cells in both the in vitro and in vivo experiments.

Researchers plan to continue researching the anticancer mechanisms behind the plant extract. They'll also study various ways to administer nimbolide to maintain its potency against pancreatic cancer.


http://www.nature.com/articles/srep19819

Edited

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