New role for a long noncoding RNA in tumor growth via altered glycolysis

New role for a long noncoding RNA in tumor growth via altered glycolysis

Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells.

Researchers demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression.

NRCP was highly upregulated in ovarian tumors, and knockdown of NRCP resulted in significantly increased apoptosis, decreased cell proliferation, and decreased glycolysis compared with control cancer cells.

In an orthotopic mouse model of ovarian cancer, siNRCP delivered via a liposomal carrier significantly reduced tumor growth compared with control treatment.

Authors identified NRCP as an intermediate binding partner between STAT1 and RNA polymerase II, leading to increased expression of downstream target genes such as glucose-6-phosphate isomerase.

Collectively, they report a previously unrecognized role of the lncRNA NRCP in modulating cancer metabolism. As demonstrated, DOPC nanoparticle-incorporated siRNA-mediated silencing of this lncRNA in vivo provides therapeutic avenue toward modulating lncRNAs in cancer.

http://www.cell.com/cell-reports/abstract/S2211-1247(15)01362-5
 
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