Researchers studied the exchange of molecules between cells, by color-coding them with red or blue cellular fluorescent 'dyes' or 'tags.' Blue cells were co-cultured with red cells and monitored to see if they exchanged cellular material, such as proteins through tunneling nanotubes (TNTs).
They observed that the function a protein involved in the transport of proteins and organelles within cells (called 'Rab8'), was affected, suggesting that this protein is a key regulator of cell-cell communication in cancer.
Live cell imaging confirmed that the transfer is contact-dependent. Importantly, the scientists experiments also showed that this process occurs in vivo.
Using two groups of mice that had green (healthy cells) and red (human cancer cells) fluorescent tags, they observed a transfer of red material into the green healthy cells of the mice's mammary fat pads.
http://www.fasebj.org/content/29/11/4695
Edited
Latest News
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Mapping microbiome in metas…
By newseditor
Posted 22 Apr
Full-length mRNA packaged i…
By newseditor
Posted 22 Apr
Glucose-sensing mechanism t…
By newseditor
Posted 21 Apr
Other Top Stories
Antidiabetic effect of drug metformin linked to iron homeostasis
Read more
Ghrelin promotes conditioning to food-related odors
Read more
Receptor for exercise hormone irisin found!
Read more
Implantable vagus nerve stimulation device aids weight loss
Read more
How exercise reduces belly fat in humans
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Neuronal activity rapidly r…
By newseditor
Posted 22 Apr
A perspective on muscle phe…
By newseditor
Posted 22 Apr
Foxp1 suppresses cortical a…
By newseditor
Posted 22 Apr
Single-cell long-read seque…
By newseditor
Posted 22 Apr
Unlocking potential: the ro…
By newseditor
Posted 22 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar