The novel discovery impinges upon the protein called SHANK which has been intensively studied in several processes in central nervous system and gene mutations in SHANK are linked to autism.
Researchers have observed that a protein called SHANK prevents the spread of breast cancer cells to the surrounding tissue. The SHANK protein has been previously studied only in the central nervous system, and it is known that its absence or gene mutations are related to autism.
Our results revealed that gene mutations in SHANK, found in autistic patients, impair SHANKs ability to prevent the adherence of both neurons and breast cancer cells. This once again demonstrates the power of basic research in facilitating our understanding of several human diseases, says senior author.
Large-scale screens aiming at find potential new genes regulating cancer cell metastasis revealed to the research team an unexpected link between brain development and tumor invasion.
Amazingly, the ability of cancer cells to adhere and migrate on their environment and invade into surrounding tissue were prevented by SHANK protein.
In cell culture experiments, the researchers found that SHANK protein limits the ability of a protein called Rap1 to activate cell adhesion receptors, integrins. This same mechanism regulated cancer cell motility as well as the morphology and branching of neurites, known to be essential for normal brain function.
The research team and their collaborators are currently assessing if SHANK proteins have other impacts on cancer cells - especially on their proliferation.
The findings were published in the journal Nature Cell Biology.
Unexpected link between cancer and autism found!
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