B cells are now recognized as key players in autoimmune diseases traditionally thought to be T cell-mediated. B cells can present antigens, which stimulate immune responses, to T cells in autoimmune diseases, but the role of B cells as antigen-presenting cells is not well understood.
Researchers examined the autoantibody response against the enzyme transglutaminase 2 (TG2) in celiac disease, an autoimmune disorder characterized by abnormal sensitivity to gluten proteins found in wheat, rye, and barley.
B cells that specifically bind epitopes in the N-terminal domain of TG2 more efficiently took up TG2-gluten complexes for presentation to gluten-specific T cells, compared with B cells that specifically recognize C-terminal TG2 epitopes.
Moreover, TG2-specific antibodies from blood samples from patients with different degrees of intestinal inflammation showed a preference for binding to N-terminal versus C-terminal TG2 epitopes. This N-terminal bias was especially pronounced in some children with recently developed celiac disease, compared with adults with established, untreated disease.
According to the authors, the results suggest that the preferential targeting of certain N-terminal TG2 epitopes is prominent shortly after disease onset, and that B cells with this form of specificity may be the main antigen-presenting cells for pathogenic gluten-specific T cells.
https://www.pnas.org/content/early/2019/07/02/1901561116
Collaboration between B cells and T cells in celiac disease
- 2,138 views
- Added
Edited
Latest News
Abusive drugs hijack natura…
By newseditor
Posted 23 Apr
Mechanism of action of the…
By newseditor
Posted 23 Apr
Role of fat in rare neurolo…
By newseditor
Posted 23 Apr
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Other Top Stories
Ultrasound disruption of blood-brain barrier
Read more
Visualizing gene expression with MRI
Read more
Imaging retinal ganglion cells
Read more
A biosensor to detect tumors at early stages
Read more
First cell culture of live adult human neurons shows potential of b…
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Exploiting pancreatic cance…
By newseditor
Posted 23 Apr
Structure of antiviral drug…
By newseditor
Posted 23 Apr
Type-I-interferon-responsiv…
By newseditor
Posted 23 Apr
Selenium, diabetes, and the…
By newseditor
Posted 23 Apr
Long-term neuropsychologica…
By newseditor
Posted 23 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar