In humans and other mammals, the female reproductive cells - the eggs or oocytes - need nourishment in order to grow and remain fertile. It is known that the egg gets its food from little arm-like feeding tubes (called filopodia) that jut out from tiny cells surrounding the egg and must poke through a thick wall coating the egg in order to feed it. Until recently, scientists did not really understand when and how those feeding tubes were constructed.
Now, a team of researchers has found out who calls the shots when it is mealtime for the growing egg, how that cell-to-cell message is communicated and how the feeding tubes themselves are generated. It turns out the egg is in charge and its communication skills are highly sophisticated. When it's time to get food, the egg sends signals to the tiny surrounding cells to make the feeding tubes, and as it grows and needs more nourishment, it signals them to make even more tubes.
These findings, which push the scope of our understanding of female fertility, were published in the journal Current Biology.
The study revealed that growth factors - especially one known as growth differentiation factor 9 - coming from the eggs drove the feeding tube multiplication and growth process, acting directly upon the genetic machinery of the follicle cells surrounding the egg. These discoveries put the spotlight directly on the egg itself, says the senior author.
"It shows that the egg is playing an active role in creating the microenvironment that it needs to continue its development," says the lead study author. "We observed that the whole process of egg development and its interaction with its environment is not static. It's very dynamic," adds first study author.
The team also found that in older mice, the cells surrounding the egg produced fewer feeding tubes. Scientists know that the eggs of older women are less successful in producing healthy babies, but they don't know the reason why. The current offers a new possible explanation.
Might it be because the cells surrounding the egg are not good at making enough feeding tubes as the egg grows older? The answer to that question, which the team is now investigating, could one day lead to the possibility of increasing fertility or even retaining fertility longer into older age, says the researcher.
Like babies, eggs send signals when 'hungry'
- 326 views