Scientists at the University of Sheffield have identified a protein, involved in the development of the human placenta, may also help embryos implant in the womb - something which could improve treatments for recurrent miscarriages and pre-eclampsia.
The pioneering study shows that a protein called Syncytin-1, which was the result of a viral infection of our primate ancestors 25 million years ago, is first secreted on the surface of a developing embryo even before it implants in the womb.
This means the protein is likely to play a major role in helping embryos stick to the womb as well as the formation of the placenta.
This fundamental understanding of the earliest stages of human embryo development is crucial for improving current treatments for a variety of stressful complications during pregnancy such as recurrent miscarriages, foetal growth restriction syndrome and pre-eclampsia - a life-threatening condition of elevated maternal blood pressure during pregnancy.
Researchers will now investigate whether the level of Syncytin-1 secretion on the pre-implantation embryo is somehow related to outcome of pregnancy in women undergoing IVF.
"Until now we didn't know this protein was expressed so early in the embryo.Interestingly the Syncytin-1 protein was mainly secreted in the cells of the embryo, called polar trophoblast cells, which will first stick to the cells of the womb called endometrial epithelial cells. In the lab we discovered the trophoblast cells that secrete Syncytin-1 not only fuse together - which in the body will form an essential barrier to protect the embryo - but also secrete nano-vesicles called exosomes.
These exosomes may communicate with cells in other areas of the mother to prepare her for pregnancy. If this doesn't happen properly at the earliest stages it may cause problems throughout pregnancy."
http://www.sheffield.ac.uk/news/nr/miscarriage-treatments-medicine-protein-preeclampsia-scientists-embryo-fetus-pregnancy-zika-1.574328
Scientists identify protein which could improve treatments for recurrent miscarriages
- 2,123 views
- Added
Edited
Latest News
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Mapping microbiome in metas…
By newseditor
Posted 22 Apr
Full-length mRNA packaged i…
By newseditor
Posted 22 Apr
Glucose-sensing mechanism t…
By newseditor
Posted 21 Apr
Other Top Stories
Curing drug-resistant infections without antibiotics
Read more
Engineered enzyme eliminates nicotine addiction in preclinical tests
Read more
Linking genes to social behavior!
Read more
Unmasking blood doping in athletes - Micro RNA to differentiate old…
Read more
Brain signaling in aggressive behavior identified!
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Neuronal activity rapidly r…
By newseditor
Posted 22 Apr
A perspective on muscle phe…
By newseditor
Posted 22 Apr
Foxp1 suppresses cortical a…
By newseditor
Posted 22 Apr
Single-cell long-read seque…
By newseditor
Posted 22 Apr
Unlocking potential: the ro…
By newseditor
Posted 22 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar