Contagious itching is hardwired in the brain!

Some behaviors -- yawning and scratching, for example -- are socially contagious, meaning if one person does it, others are likely to follow suit. Now, researchers have found that socially contagious itching is hardwired in the brain.

Studying mice, the scientists have identified what occurs in the brain when a mouse feels itchy after seeing another mouse scratch. The discovery may help scientists understand the neural circuits that control socially contagious behaviors.

The study is published in the journal Science.

"Itching is highly contagious," said principal investigator. "Sometimes even mentioning itching will make someone scratch. Many people thought it was all in the mind, but our experiments show it is a hardwired behavior and is not a form of empathy."

For this study, the team put a mouse in an enclosure with a computer screen. The researchers then played a video that showed another mouse scratching.

"Within a few seconds, the mouse in the enclosure would start scratching, too," senior author said. "This was very surprising because mice are known for their poor vision. They use smell and touch to explore areas, so we didn't know whether a mouse would notice a video. Not only did it see the video, it could tell that the mouse in the video was scratching."

Next, the researchers identified a structure called the suprachiasmatic nucleus (SCN), a brain region that controls when animals fall asleep or wake up. The SCN was highly active after the mouse watched the video of the scratching mouse.

When the mouse saw other mice scratching -- in the video and when placed near scratching littermates -- the brain's SCN would release a chemical substance called GRP (gastrin-releasing peptide). In 2007, the team identified GRP as a key transmitter of itch signals between the skin and the spinal cord.

"The mouse doesn't see another mouse scratching and then think it might need to scratch, too," senior author said. "Instead, its brain begins sending out itch signals using GRP as a messenger."

The team also used various methods to block GRP or the receptor it binds to on neurons. Mice whose GRP or GRP receptor were blocked in the brains' SCN region did not scratch when they saw others scratch. But they maintained the ability to scratch normally when exposed to itch-inducing substances.

The senior author believes the contagious itch behavior the mice engaged in is something the animals can't control.

"It's an innate behavior and an instinct," senior author said. "We've been able to show that a single chemical and a single receptor are all that's necessary to mediate this particular behavior. The next time you scratch or yawn in response to someone else doing it, remember it's really not a choice nor a psychological response; it's hardwired into your brain.

https://medicine.wustl.edu/news/brain-hardwired-to-respond-to-others-itching/