A study published in the journal Nature Communications has pinpointed a number of areas of the human genome that may help explain the neonatal origins of chronic immune and inflammatory diseases of later life, including type 1 diabetes, rheumatoid arthritis and coeliac disease.

The research identified several genes that appear to drive disease risk at birth, and which could be targeted for therapeutic intervention to stop these diseases in their tracks, well before symptoms occur.

The senior author said chronic immune and inflammatory diseases of adulthood often originated in early childhood, with an individual's genetic make-up causing changes to the function of different genes involved in disease.

For this study, the team collected cord blood samples from more than 100 Australian newborns as part of the Childhood Asthma Study, and investigated the role of genetic variation in DNA in changing how genes are expressed in the two main arms of the immune system.

The neonatal immune cells were exposed to certain stimuli, to see how the cells responded and to identify genetic variants that changed these responses.

"We looked for overlap between these genetic signals and those that are known to be associated with diseases where we know the immune system plays a role," the senior author said.

"We then used statistical analysis to search for possible links between the cell response in newborns and immune diseases in adulthood."

Chronic immune diseases - including type 1 diabetes, coeliac disease and multiple sclerosis - are caused by an overactive immune system and affect about 5 per cent of Australians. Allergies are immune-mediated too and affect one in five Australians, with hay fever, asthma, eczema, anaphylaxis and food allergies the most common. Inflammation and autoimmunity are also known to be driving factors in cardiovascular diseases, for example when an overactive immune system mistakenly attacks the heart.

The lead author of the study said the findings were unique in their scale, with thousands of genetic variants driving gene expression across different immune and inflammatory conditions, some of which had wide-ranging effects.

"Our study showed the potential roles of gene expression in disease development, which has helped us to better understand the link between DNA variation and disease risk," the lead said.
"To date, similar studies have only been conducted in adult immune cells. Given the huge difference between neonatal and adult immunity, it is not surprising to see many signals that were unique to newborns."

"Common diseases, such as type 2 diabetes and cardiovascular disease, tend to be polygenic - influenced by a large number of genetic variants scattered throughout the genome, which combine with environmental and lifestyle factors. By using new genomic technology and supercomputing capabilities, we can sift through this DNA data and piece together the puzzles that underlie each disease.

"With so many diseases sharing a root in the immune system and inflammation we can leverage this information to better understand where each disease has a molecular weak spot and to what extent these are shared among different diseases.

"We've shown this can be dissected using genetics and polygenic risk, hopefully leading to targeted preventative interventions for those who need them most, with the aim of keeping people living healthier for longer" the senior author said.

https://www.nature.com/articles/s41467-020-17477-x

http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fneonatal-genetics-of&filter=22