More genes linked with stroke identified!

Researchers are part of an international team that discovered 61 additional genetic loci associated with stroke and six genes that are potential targets for drug therapy to prevent or treat stroke. The findings, published in Nature, are in 2.5 million people from five different ancestries, more than 200,000 of whom had a stroke. Members of the GIGASTROKE consortium conducted the research.

Stroke is the second leading cause of death worldwide, responsible for approximately 12% of total deaths, and a major contributor to years of life lost or lived with disability. Loci are the physical locations of genes on chromosomes in cells and have been called genetic street addresses.

“The population studied in this paper has a fairly global representation including Africa, South Asia, East Asia, Europe and Latin America,” a co-author said. “Interestingly, one of the groups that remains not very well represented is the U.S. Hispanic population, so there is still work to be done.”

Stroke is a major risk factor for dementia, and there is significant overlap between the conditions, Seshadri said. Stroke affects small vessels, endothelial cells that line blood vessels, and cells called pericytes that are important for blood vessel formation and other functions. Vascular cognitive impairment and dementia also affect small vessels, endothelial cells and pericytes, the co-author said.

“There is common biology between stroke and dementia, and there are research methods used in this project to study stroke genetics that will make us stronger in studying dementia,” said another co-author.

Drug targets currently known in Alzheimer’s disease and related dementias have not led to effective therapies so far, the co-author noted. “I really think discovering novel biology and going after it is one of the most promising avenues for finding new drug targets and medications to treat dementia,” the author said.