Intracerebral haemorrhage, and bleeding into the brain tissue, is a devastating neurological condition affecting millions of people annually. It has a high mortality rate, while survivors are affected by long-term neurological deficits. No medication has been found to support brain recovery following hemorrhage.
In an international collaboration, researchers investigated whether a protein called cerebral dopamine neurotrophic factor (CDNF) has potential as a treatment for brain hemorrhage.
Researchers suggest that cerebral dopamine neurotrophic factor, a protein being currently tested for Parkinson’s disease treatment, also has therapeutic effects and enhances immune cell’s response after brain haemorrhage.
The authors found that the administration of cerebral dopamine neurotrophic factor accelerates hemorrhagic lesion resolution, reduces brain swelling, and improves functional outcomes in an animal model of brain hemorrhage.
“Surprisingly, we found that cerebral dopamine neurotrophic factor acts on immune cells in the bleeding brain, by increasing anti-inflammatory mediators and suppressing the production of the pro-inflammatory cytokines that are responsible for cell signalling. This is a significant step towards the treatment of injuries caused by brain haemorrhage, for which we currently have no cure,” says .the senior author
Another author comments, "It's interesting to note that after a bleeding episode, the brain contains a lot of waste and debris. Cerebral dopamine neurotrophic factor encourages immune cells in the brain to consume and remove the waste and debris, which is essential for the brain’s recovery!”.
The administration of cerebral dopamine neurotrophic factor also resulted in the alleviation of cell stress in the area that surrounds the hematoma.
Finally, the researchers demonstrated that systemic administration of cerebral dopamine neurotrophic factor promotes scavenging by the brain’s immune cells after brain haemorrhage and has beneficial effects in an animal model of brain haemorrhage.
https://www.nature.com/articles/s41419-022-05520-2
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Faugmenting-hematoma&filter=22
A novel waste removal factor treats brain haemorrhage
- 747 views
- Added
Latest News
Citrullination is a key pla…
By newseditor
Posted 14 Sep
Senolytic therapy clinical…
By newseditor
Posted 14 Sep
Genetic tools probe microbi…
By newseditor
Posted 13 Sep
A secret passage for mutant…
By newseditor
Posted 11 Sep
Specialized T cells in the…
By newseditor
Posted 10 Sep
Other Top Stories
If you make impulsive choices you should blame your parents – it's…
Read more
How 1 gene contributes to 2 diseases
Read more
New aspect of gene regulation
Read more
Epigenetic regulation of puberty
Read more
DNA repair gene mutation leads to anemia!
Read more
Protocols
D-LMBmap: a fully automated…
By newseditor
Posted 30 Sep
Genetic manipulation of Pat…
By newseditor
Posted 13 Sep
Single-nucleus RNA sequenci…
By newseditor
Posted 08 Sep
Engineering RNA export for…
By newseditor
Posted 25 Aug
ATP production from electri…
By newseditor
Posted 21 Aug
Publications
Alteration in the chromatin…
By newseditor
Posted 30 Sep
Identification of genes req…
By newseditor
Posted 29 Sep
Mitochondrial degradation:…
By newseditor
Posted 29 Sep
The promise of new anti-obe…
By newseditor
Posted 29 Sep
Timing of lifespan influenc…
By newseditor
Posted 16 Sep
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar