Diets rich in fiber have long been associated with an array of positive outcomes, chief among them healthy hearts and arteries protected from the ravages of atherosclerosis, the accumulation of fatty plaques linked to heart attacks and strokes.
Figuring out just how the fiber we eat manages to protect our heart, however, has been challenging.
One clue has come from the revolution in understanding the effect the diverse microbial community that populates our guts has on our health. Our microbiome helps us process our food, particularly fiber. Perhaps these beneficial microbes somehow turned indigestible plant parts into heart health. But the link was uncertain.
In support of a microbial connection between fiber and heart health, researchers have identified a particular fatty acid as the mechanism behind certain protective effects of a high-fiber diet in a mouse model. Known as butyrate, this fatty acid is produced by certain bacteria in the gut as they digest plant fiber.
The scientists showed that mice that harbored the butyrate-producing bacteria Roseburia and that also ate a high-fiber diet suffered from less atherosclerosis and had reduced inflammation compared to mice without the bacteria. Mice that hosted Roseburia but that ate a low-fiber diet were not protected, because without fiber the bacteria produced little butyrate.
Mice fed a slow-release form of butyrate itself were also protected from atherosclerosis, pointing to the molecule as a key arbiter of the fiber-heart link. The study was published recently in the journal Nature Microbiology.
So the key to reducing atherosclerosis may be reducing overall inflammation, especially in the bloodstream. Keeping inflammation down depends in part on having a strong gut barrier. When inflammatory molecules break off of beneficial bacteria and leech out of the gut and into the bloodstream, they can trigger widespread inflammation. To keep these molecules at bay, healthy gut cells form strong attachments to one another, creating an intact barrier. But that attachment can be broken up.
To study butyrate's effect on the gut and atherosclerosis, researchers colonized germ-free mice with specific communities of bacteria, either with or without the butyrate-producing Roseburia. Those mice were then fed diets either rich or lacking in fiber, which Roseburia processes into butyrate.
The researchers found that mice hosting Roseburia had lower levels of several markers of inflammation and a reduced extent of atherosclerosis -- but only if they ate a high-fiber diet. Without fiber, Roseburia levels plummeted and the mice were not protected from atherosclerosis. The researchers used mice genetically susceptible to atherosclerosis because mice do not naturally develop the disease.
To determine if butyrate was the true cause of Roseburia's protective effects, the authors fed the fatty acid to mice without any butyrate-producing bacteria. Because pure butyrate would quickly be taken up by cells in the upper intestine, the authors fed mice a slow-release version that made it intact to the lower guts.
The slow-release butyrate reduced the extent of fatty plaques by about a third, and reduced other markers of inflammation and atherosclerosis, suggesting that the fatty acid formed a major component of Roseburia's anti-atherosclerosis effects.
Previous work indicated that humans with cardiovascular disease harbor lower levels of Roseburia and other butyrate-producing bacteria. The new study is one of the first to identify a clear cause for a previously mysterious link between dietary fiber, microbiomes and health. However, the researchers caution that the results don't point to a butyrate as a new, simple supplement for heart health -- fiber from whole foods still appears to be the ideal way to support a healthy gut.
https://news.wisc.edu/beneficial-gut-bacteria-metabolize-fiber-to-improve-heart-health-in-mice/
https://www.nature.com/articles/s41564-018-0272-x
Latest News
Abusive drugs hijack natura…
By newseditor
Posted 23 Apr
Mechanism of action of the…
By newseditor
Posted 23 Apr
Role of fat in rare neurolo…
By newseditor
Posted 23 Apr
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Other Top Stories
Mitochondrial signaling to control excessive inflammation
Read more
Monocyte-derived S1P in the lymph node regulates immune responses
Read more
Gut's immune system helps regulate food processing
Read more
How heart disease in the elderly is exacerbated?
Read more
Auto-aggressive immune cells attack liver cells to cause fatty liver
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Sex-specific modulation of…
By newseditor
Posted 24 Apr
Exploiting pancreatic cance…
By newseditor
Posted 23 Apr
Structure of antiviral drug…
By newseditor
Posted 23 Apr
Type-I-interferon-responsiv…
By newseditor
Posted 23 Apr
Selenium, diabetes, and the…
By newseditor
Posted 23 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar