Body parts respond to day and night independently from brain

Body parts respond to day and night independently from brain


Can your liver sense when you're staring at a television screen or cellphone late at night? Apparently so, and when such activity is detected, the organ can throw your circadian rhythms out of whack, leaving you more susceptible to health problems.

That's one of the takeaways from two new studies by scientists and published in the journal Cell, The authors used specially bred mice to analyze the network of internal clocks that regulate metabolism. Although researchers had suspected that the body's various circadian clocks could operate independently from the central clock in the hypothalamus of the brain, there was previously no way to test the theory, said the senior author of one of the studies.

To overcome that obstacle, scientists figured out how to disable the entire circadian system of the mice, then jump-start individual clocks. For the experiments reported in the Cell papers, they activated clocks inside the liver or skin.

"The results were quite surprising," said said one of the paers senior author. "No one realized that the liver or skin could be so directly affected by light."

For example, despite the shutdown of all other body clocks, including the central brain clock, the liver knew what time it was, responded to light changes as day shifted to night and maintained critical functions, such as preparing to digest food at mealtime and converting glucose to energy.

Somehow, the liver's circadian clock was able to detect light, presumably via signals from other organs. Only when the mice were subjected to constant darkness did the liver's clock stop functioning.
In upcoming studies, the researchers will phase in other internal clocks to see how different organs communicate with each other, the author said.

"The future implications of our findings are vast," the author noted. "With these mice, we can now begin deciphering the metabolic pathways that control our circadian rhythms, aging processes and general well-being."

In earlier studies, the authors had examined how circadian clocks can be rewired by such factors as sleep deprivation, diet and exercise. Exposure to computer, television or cellphone light just before bed can also scramble internal clocks.

Because of modern lifestyles, it's easy for people's circadian systems to get confused, the author said. In turn, that can lead to depression, allergies, premature aging, cancer and other health problems. Further mice experiments could uncover ways to make human internal clocks "less misaligned," the author added.


https://news.uci.edu/2019/05/30/uci-research-helps-shed-new-light-on-circadian-clocks/

https://www.cell.com/cell/fulltext/S0092-8674(19)30507-0

https://www.cell.com/cell/fulltext/S0092-8674(19)30444-1

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