Researchers have discovered that a growth factor protein, called brain-derived neurotrophic factor (BDNF), and its receptor, tropomyosin receptor kinase B (TrkB) affects social dominance in mice. The research has implications for understanding the neurobiology of aggression and bullying.
"Humans and rodents are social animals. Our every interaction follows rules according to a social hierarchy. Failure to navigate this hierarchy can be detrimental." explained senior author. "Our paper may be the first to demonstrate that specific molecular signalling pathways in specialised nerve cells, in a particular location in the brain, are important for the balanced navigation of social hierarchies."
Difficulties in navigating these hierarchies can lead to problems like aggression and bullying. "Given the heavy societal cost of bullying and aggression, understanding the biological causes is a step towards their effective prevention and treatment," the senior author added.
Activity within the brain is mediated by circuits made up of excitatory neurons, which ramp up activity, and GABA-ergic interneurons, which inhibit and quiet the excitatory activity. Previous studies have shown that BDNF-TrkB signalling is important for the maturation of GABA-ergic interneurons and the development of nerve circuits in the brain. But researchers have not been able to pinpoint the behavioural consequences of disrupted BDNF-TrkB signalling.
The team generated transgenic mice in which the TrkB receptor was removed specifically in the GABAergic interneurons in the area of the brain regulating emotional and social behavior, known as the corticolimbic system. The transgenic mice exhibited unusual aggressive behavior when housed together with normal mice. To understand the origin of this behavior, the team conducted behavioral tests. They found that the mice were not being aggressive to protect their territory. They were also not being aggressive because they were stronger; the transgenic mice were injured more than other mice during acts of aggression. Instead, their aggressive behavior was a result of increased fighting for status and dominance over other mice in the group.
The researchers found that due to the loss of BDNF-TrkB, GABA-ergic interneurons in these transgenic mice supplied weaker inhibition to surrounding excitatory cells, which became overactive. They proceeded to shut down excitatory neurons in a specific area of the transgenic mice brains, which re-established the "excitatory/inhibitory" balance and which "instantaneously reversed the abnormal social dominance", says the first author of the paper.
A significant amount of research has focused on the roles of family and peer networks on aggressive behavior. This study, together with other recently published findings, demonstrates that genetic and biological factors can play an unexpected role in social behaviors, said the senior author.
Brain signaling in aggressive behavior identified!
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