Understanding the mechanisms that precisely direct cerebrovascular blood flow to satisfy the brain's ever-changing energy needs has, to date, eluded scientists. Neurons consume an enormous amount of the body's energy supplies -- about 20 percent -- yet lack their own reserves, so are reliant on blood to deliver nutrients.
Previously, capillaries were thought to be passive tubes and the arterioles were thought to be the source of action. Now, researchers have discovered that capillaries actively control blood flow by acting like a series of wires, transmitting electrical signals to direct blood to the areas that need it most.
To achieve this feat, the capillary sensory network relies on a protein (an potassium ion channel) that detects increases in potassium during neuronal activity. Increased activity of this channel facilitates the flow of ions across the capillary membrane, thereby creating a small electrical current that generates a negative charge--a rapidly transmitted signal -- that communicates the need for additional blood flow to the upstream arterioles, which then results in increased blood flow to the capillaries.
The team's study also determined that if the potassium level is too high, this mechanism can be disabled, which may contribute to blood flow disturbances in a broad range of brain disorders.
"These findings open new avenues in the way we can investigate cerebral diseases with a vascular component," says co-first author of the study published in the journal Nature Neuroscience.
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4533.html
Controlling blood flow to the brain!
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