Different types of oligodendrocytes in people with MS

Different types of oligodendrocytes in people with MS


Fresh insights into the types of cells found in the brains of people with multiple sclerosis could help develop improved therapies, research has found. The study focused on cells in the brain that help to repair damage to nerve cells caused by the disease.

Researchers identified various types of these cells - called oligodendrocytes. People with MS have different types of oligodendrocytes than healthy people, the study found. The findings could shed new light on how the disease progresses and could also help scientists develop treatments.

Experts analysed post-mortem brain samples from five people without neurological disease and four people with the most advanced form of multiple sclerosis, called progressive MS. The team used an advanced genetic analysis technique called single nuclear RNA-Seq. This technique provides a snapshot of all the genes that have been switched on in a single brain cell, providing insights into how each individual cell functions. By doing this on thousands of brain cells, the approach can build a detailed picture of all the cell types that are present in the brain from that person.

The researchers found there are several types of oligodendrocytes, and that the ratio of these cells in people with MS differs from healthy people. These differences suggest the oligodendrocytes are functioning differently in the brains of people with MS, which might be key to understanding how disease progresses, the researchers say.

MS occurs when the protective sheath that surrounds nerve cells - called myelin - becomes damaged. This means that nerve cells cannot transmit signals around the body as effectively. It also leaves nerve cells vulnerable to damage, and eventually the nerves can die.

Oligodendrocytes are found in the brain and spinal cord where they repair damaged myelin. In people with MS, this process does not work as well as in healthy people. Many treatments under development for MS are designed to target oligodendrocytes in the hope of boosting myelin repair.

Studies with mice had previously identified several types of oligodendrocytes in the mouse brain, suggesting each have slightly different functions. This is the first study to show that people also have several types of oligodendrocytes in the brain. Researchers say the differences in types of oligodendrocytes they found in people with MS might explain why their myelin repair process does not work as well.

The study published in Nature also found people have and different types of oligodendrocytes than mice. The findings suggest the cells may work differently in each species. This could have important implications for how findings from mouse studies of MS are interpreted.

https://www.nature.com/articles/s41586-019-0903-2

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