Dopamine cells influence higher order cognition of prefrontal cortex of the brain

Dopamine cells influence higher order function of prefrontal cortex of the brain


Anyone who has savored a bite of chocolate or glanced at each new blinking notification on their smart phone is familiar with dopamine.

But that is not all dopamine does. This chemical neurotransmitter also plays a fundamental role in the prefrontal cortex of the brain, which controls higher functions such as paying attention, staying motivated, and making decisions.

Now, research in rodents reveals for the first time how dopamine changes the function of the prefrontal cortex. In a study published in the journal Cell Reports, researchers found that dopamine has little effect on individual cells. Instead, it generates sustained activity in the ensemble of cells in the prefrontal cortex that lasts for up to 20 minutes.

"Ensemble brain cell activity, just like ensembles of musicians who perform together, can have a different and greater effect than the activity of individual neurons" said the senior author.

The coordinated ensemble activity initiated by dopamine lasted for many minutes after it was released.

"This may provide a mechanism by which dopamine supports complex functions that have to be sustained, such as motivation and attention to complete a task," the senior author said.

Using optogenetic methods in the brains of rodents during active behavior, researchers stimulated dopamine neurons in the brain with light and then recorded the response in the prefrontal cortex. They detected a relatively weak signal among individual cells. However, a computational method of analysis discerned multiple forms of coordinated activity among cells in the prefrontal cortex that lasted several minutes following the initial burst of light.

In addition to the impact of dopamine on the ensemble activity, the study demonstrated that dopamine cells increase oscillatory activity, or brain waves, at the gamma range. Disruptions in brain oscillation at this high frequency had been previously linked to attention, as well disorders such as schizophrenia and ADHD, but the cause of this disruption is not well understood.

The discovery of dopamine's role provides fresh insight into a key mechanism in the brain. Dopamine in the prefrontal cortex of the brain plays a role in almost all aspects of high order cognition, including attention and behavioral flexibility. It's also implicated in motivational and cognitive deficits of brain illnesses such as schizophrenia, addiction and attention-deficit/hyperactivity disorder.

"This could explain why you need dopamine for sustained attention," the senior author said. "It can help us understand how in disorders like ADHD, where there could be a dopamine deficit, that the impact may not be at individual neuron but the ensemble level."
 
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30319-5


http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fdopamine-modulation-of&filter=22

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