Exercise Increases Dopamine Release in Mice

Exercise increases dopamine signaling in the motor areas of mice, according to research recently published in JNeurosci.

It’s no secret exercise is good for the brain — working out can improve mood, sharpen memory, and stave off cognitive decline. Exercise even improves motor behavior in people with Parkinson’s disease, but the exact mechanism is not known. One possibility is through an increase in dopamine, a neurotransmitter needed for motor and emotional control that declines as the disease progresses.

The researchers compared dopamine signaling in mice after 30 days of voluntary wheel running or inactivity. In the runner mice, dopamine release in the striatum (a motor area) increased in response to electrical stimulation, while there was no change in sedentary mice.

The increased dopamine release remained even a week after the exercise ended. The researchers also measured increased levels of brain-derived neurotrophic factor (BDNF), a protein involved in neuron health, in the striatum of active mice.

When the researchers repeated the experiments in a genetic mouse model lacking BDNF, there was no difference in dopamine release between the active and sedentary mice, suggesting BDNF catalyzes increased dopamine signaling. Future studies will examine if the relationship holds true in a mouse model of Parkinson’s disease, and if exercise can improve motor outcomes. 

https://www.jneurosci.org/content/early/2022/04/27/JNEUROSCI.2273-21.2022