Gene regulating severity of tissue damage caused by rheumatoid arthritis discovered

Gene regulating severity of tissue damage caused by rheumatoid arthritis discovered

Rheumatoid arthritis (RA), an autoimmune disease that causes inflammation, pain, stiffness and damage to the joints of the feet, hips, knees, and hands.

Although there is no cure for RA, new effective drugs are increasingly available to treat the disease and prevent deformed joints. Self-management of the condition by patients, including exercise, is also known to reduce pain and resulting disability.

Scientists analysed DNA samples and biopsy samples from joints of over 1,000 Rheumatoid arthritis patients in the United Kingdom and Ireland and  have identified a new protein (C5orf30) which regulates the severity of tissue damage caused by RA.

They also point to the possibility that increasing the levels of C5orf30 in the joints might be a novel method of reducing tissue damage caused by RA.
 
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