Humans and fruit flies may have not shared a common ancestor for hundreds of millions of years, but the neurons that govern our circadian clocks are strikingly similar.
Now, researchers have made a discovery in fruit flies that may teach us a little more about our own sleep cycles. Using the fruit flies, they showed how circadian clock neurons use thermoreceptors to constantly monitor the temperature of their environment. They found even mild changes in temperature have physiological effects on clock neurons that control sleep timing.
This discovery will help researchers understand how neurons are using environmental temperature in addition to light to regulate sleep timing in mammals, including humans. Their study is published in the journal Nature.
"Decades of work from recent Nobel Prize winners and many other labs have have actually worked out the details of how light is able to adjust the clock, but the details of how temperature was able to adjust the circadian clock were not well understood," said first author of the study.
"Going forward, we can ask questions of how these two stimuli are processed and integrated into the clock system, and how this has effects on our sleep behavior and other physiological processes."
Circadian clocks are biochemical mechanisms that allow living things to organize their sleep and waking across the 24-hour cycle of a day. Researchers know that circadian clocks in mammals control the internal body temperature to drive sleep patterns, says principal investigator of the study. For example, we think of the human body temperature as a steady 98.6 degrees, senior author said, but actually, our body temperature changes throughout the day.
"In fact, it's fluctuating," author said. "The circadian system produces a daily rhythm in temperature which is an important cue for when it's time to go to sleep."
As we're coasting toward bedtime, these circadian clocks cool our internal body temperature. As we're gliding toward wakefulness, these clocks turn up the heat. This is regardless of the temperature of the room we're sleeping in. But showing that circadian clock neurons in fruit flies use external temperature to trigger sleep suggests that some clock neurons in humans could be similarly sensitive.
To study how the fruit fly neurons responded to external temperature, researchers developed an optical imaging and temperature control system that enabled them to take a snapshot of neural activity in the circadian clock network of fruit flies when the flies are exposed to heat or cold stimulus.
"It looks like clock neurons are able to get the temperature information from external thermoreceptors, and that information is being used to time sleep in the fly in a way that's fundamentally the same as it is in humans," senior author said. "As temperature drops, these neurons that promote sleep become excited, and that really entrains the sleep activity cycle to external temperature cycles. It's precisely what happens to sleep in mammals when internal temperature drops."
How body clock neurons use ambient temperature to regulate sleep time
- 433 views