How formaldehyde affects epigenetics

Epigenetics, the chemical mechanisms that controls the activity of genes, allows our cells, tissues and organs to adapt to the changing circumstances of the environment around us. This advantage can become a drawback, though, as this epigenetic regulation can be more easily altered by toxins than the more stable genetic sequence of the DNA.

An article recently published study in Science  demonstrates that the substance called formaldehyde, commonly present in various household and cosmetic products, in polluted air, and widely used in construction, is a powerful modifier of normal epigenetic patterns.

The research has focused on investigating the effects of high concentrations of formaldehyde in the body, a substance already been associated with an increased risk of developing cancer (nasopharyngeal tumours and leukaemia), hepatic degeneration due to fatty liver (steatosis) and asthma. The author points out that this is relevant because “formaldehyde enters our body mainly during our breathing and, because it dissolves well in an aqueous medium, it ends up reaching all the cells of our body”.

“This substance is especially concentrated in various products used in construction, furniture manufacturing, the textile industry and some hair products", comments the author. Going a step further, the author stresses this vision pointing out that “formaldehyde is not only a significant environmental hazard, often found in polluted fumes, but it can also be generated within our bodies through the metabolism of common dietary substances like the sweetener aspartame. Moreover, our cells are continually producing formaldehyde, a known mutagen that can lead to cancer”.

As an overview of the research, the author points out that "we have discovered that formaldehyde is an inhibitor of the MAT1A protein, which is the main producer of S-Adenosyl-L-Methionine (SAM) and this last molecule is the universal donor of the chemical group "methyl" that regulates epigenetic activity. Specifically, we found that exposure to formaldehyde induced a reduction in SAM content and caused the loss of methylation of histones, proteins that package our DNA and control the function of thousands of genes”.

Altogether, this work reveals an even more concerning aspect of formaldehyde's toxicity. The author summarizes it as “we have discovered that formaldehyde has the capacity to modify the epigenetic landscape of our cells, which might contribute to the well-documented carcinogenic properties of formaldehyde.”

The epigenetic changes caused by the toxic agent could directly contribute to the origin of the mentioned diseases, beyond its known mutagenic properties. On this regard, the author informs that "International health authorities are already restricting the use of formaldehyde as much as possible, but there are still areas of work where high levels of it are used, such as in the manufacture of resins, the production of plastic, industrial foundries or the cosmetics industry. In addition, it also originates during the combustion of automobile gasoline and in tobacco smoke, thus, environmental and health policies aimed at reducing our exposure to the characterized substance should be promoted.”