How TB compromises our immune system

How TB compromises our immune system

Scientists have discovered both how TB puts the brakes on our immune engines and how we can kick-start those engines back into gear - providing hope that improved treatment options could soon be on the horizon.

Although ancient, TB is still the world's deadliest infectious disease. While it is rampant in Africa, the growing problem of antibiotic resistance is posing a significant threat worldwide.

Part of TB's success as a pathogen is because of its ability to infect the cells of our immune system, which are normally tasked with responding to the infection. It infects our lung macrophage cells and then manipulates them to its benefit - creating a safe home for it to hide out unperturbed, sometimes for years.

In surprising results, published in the journal Cell Reports, the researchers found that persistent infection of these macrophages with TB puts the brakes on the glucose-fuelled engine. This essentially shuts down our natural response to infection, which allows the bacteria to hide out unperturbed.

Specifically, the authors found a small RNA molecule (which comprises tiny pieces of genetic information) which the bacteria promotes and which targets key enzyme phosphofructokinase-muscle form (PFK-M) that act as pumps in our immune engines to commit glucose to promote the anti-bacterial response.

When the bacteria promotes this small RNA molecule, which is termed microRNA-21, PFK-M is inhibits and glucose is not used in the same way. This then allows the bacteria to escape and thrive.

Although this newly identified pathway is corrupted by the bacteria, the study also yielded some hope for the future.

The senior author explained: "We found that when TB-infected cells are treated with a key 'Interferon gamma protein signal' which is normally produced following vaccination, they will remove this microRNA to effectively relieve the brake and restore our normal immune response."

"What is particularly promising from a societal impact perspective is that as well as increasing our knowledge of how TB corrupts our normal immune response to infection, our identification of the microRNA-21 means that scientists should be able to develop improved immunotherapies or vaccine strategies to help in the fight against TB infection."