Credit: USC
Abnormality with special cells that wrap around blood vessels in the brain leads to neuron deterioration, possibly affecting the development of Alzheimer's disease, a US research study reveals.
"Gatekeeper cells" called pericytes surround blood vessels. They contract and dilate to control blood flow to active parts of the brain. A glitch with gatekeeper cells that surround capillaries may restrict blood and oxygen supply to active areas of the brain, gradually causing neuron loss that might have important implications for Alzheimer's disease (AD).
This study was the first of its kind to use a pericyte-deficient mouse model to test how blood flow is regulated in the brain. The goal was to identify whether pericytes could be an important new therapeutic target for treating neuron deterioration.
"Vascular problems increase the risk of cognitive impairment in many types of dementia, including Alzheimer's disease," said the co- first author of the study. "Pericytes play an important part in keeping your brain healthy.“
Pericyte dysfunction suffocates the brain, leading to metabolic stress, accelerated neuronal damage and neuron loss. To test the theory, researchers stimulated the hind limb of young mice deficient in gatekeeper cells and monitored the global and individual responses of brain capillaries, the smallest blood vessels in the brain. The global cerebral blood flow response to an electric stimulus was reduced by about 30 percent compared to normal mice, denoting a weakened system.
Relative to the control group, the capillaries of pericyte-deficient mice took 6.5 seconds longer to dilate. Slower capillary widening and a slower flow of red blood cells carrying oxygen through capillaries means it takes longer for the brain to get its fuel.
As the mice turned 6 to 8 months old, global cerebral blood flow responses to stimuli progressively worsened. Blood flow responses for the experimental group were 58 percent lower than that of their age-matched peers. In short, with age, the brain's malfunctioning vascular system exponentially worsens.
The study helped us to understand the role of gatekeeper cells, which is to ensure adequate oxygen and energy supply to brain cells.
Previous studies have identified that patients with AD, ALS and other neurodegenerative disorders experienced changes to the blood flow and oxygen being supplied to the brain and that pericytes died.
In the present study, loss of these gatekeeper cells (Pericytes), leads to impaired blood flow and insufficient oxygen delivery to the brain. Further study needs to identify, what kills Pericytes in AD?
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4489.html
Latest News
Mutations in noncoding DNA…
By newseditor
Posted 24 Apr
More influence of environme…
By newseditor
Posted 24 Apr
The assembly of the human c…
By newseditor
Posted 24 Apr
Wiring of the human neocortex
By newseditor
Posted 24 Apr
Abusive drugs hijack natura…
By newseditor
Posted 23 Apr
Other Top Stories
Role of mitochondrial enzyme in Alzheimer's disease
Read more
Microglia protect against brain injury
Read more
Breast cancer drug found to reduce seizures
Read more
Cells carry 'memory' of injury, which could reveal why chronic pain…
Read more
Disrupted REM sleep can derail memory formation
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Massively parallel screen u…
By newseditor
Posted 24 Apr
Distinct genetic and enviro…
By newseditor
Posted 24 Apr
Hippocampus-to-amygdala pat…
By newseditor
Posted 24 Apr
Integrative spatial analysi…
By newseditor
Posted 24 Apr
Time-series reconstruction…
By newseditor
Posted 24 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar