The brain's response to alcohol varies based on individual preferences, according to new research in rats published in eNeuro.

Not everyone is prone to developing an alcohol use disorder. Some people can drink every day without acquiring a dependence, yet far less drinking may drive another person into addiction. This difference may be explained by how the brain interprets alcohol as a reward. The orbitofrontal cortex (OFC) stores reward value and regulates reward seeking, so OFC activity corresponds to individual preferences for drugs. Its malfunctioning may be involved in drug use disorders.

To see if the same pattern held true for alcohol, the authors measured the OFC activity of rats while they alternated consuming sugar and alcohol.

Neurons in the OFC behaved differently in each rat but correlated with how much alcohol the rat consumed when given free access -- a marker of preference. The OFC in high-drinking rats responded to alcohol in a similar fashion to sugar, a universally rewarding substance to rats. But OFC responses to alcohol were suppressed in low-drinking rats, a sign that they did not find it as rewarding as sugar. If the brains of high-drinking rats find alcohol more rewarding than low-drinking rats, they may have a higher risk for developing a dependence.

https://www.eneuro.org/content/early/2020/07/13/ENEURO.0402-19.2020

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