Prostate cancer recurrence linked to DNA repair enzyme!

Prostate cancer recurrence linked to DNA repair enzyme!

Ground breaking research could reduce the recurrence of prostate cancer in males, a new study in the journal Nature Communications reports.

During this in depth study, an international team of researchers investigated the impact of anti-hormone therapy on samples taken from patients with prostate cancer.

Anti-hormone therapy is a commonly prescribed treatment for cancer of the prostate, which helps to reduce the levels of male hormones - that stimulate cancer cells to grow - in the gland.

Researchers discovered that an inadvertent consequence of anti-hormone therapy treatment is the activation of the DNA repair enzyme, PARP.

The triggering of PARP enables cancer cells to withstand anti-hormone therapy treatment, causing cells to cultivate and develop into a more aggressive form.

To be effective and reduce recurrence of cancer in the prostate, researchers found that prescribing PARP inhibitors, a drug commonly used in breast cancer, alongside anti-hormone therapy treatment may benefit men with prostate cancer. PARP inhibitors prevent DNA repair causing cancer cells to die rather than repair.

Lead author said: "Prostate cancer is a devastating illness with a high death rate. Our exciting discovery will help remedy this and increase chances of survival for the thousands of men who contract the disease every year.

"Our research shows that anti-hormone treatment could be combined with PARP inhibitor to prevent the progression of the disease."

"The next step is to carry out clinical trials to test if this treatment combination is safe to use in patients and if it helps more men survive the disease."

This exciting new discovery offers hope to thousands of males and will limit the recurrence of prostate cancer.