Newborns at risk for Type 1 diabetes because they were given antibiotics may have their gut microorganisms restored with a maternal fecal transplant, according to a new study.
The study, which involved genetic analysis of mice, appears in the journal Cell Host & Microbe.
The findings suggest that newborns at risk for Type 1 diabetes because their microbiome - the trillions of beneficial microorganisms in and on our bodies - were disturbed can have the condition reversed by transplanting fecal microbiota from their mother into their gastrointestinal tract after the antibiotic course has been completed.
Type 1 diabetes is the most common autoimmune disease in childhood.
"Our previous work has shown that exposing young animals to antibiotics perturbs the microbiome, which may change age-associated immunity and organ-specific inflammation, increasing risk of immune-mediated diseases," said the co-author.
The study compared mice that were exposed to antibiotics between days 5 and 10 of life and given a transplant of maternal microbiota up to a week later, and those that were not. The researchers found that the mice given the transplant had their microbiome partially restored and their diabetes risk brought back to the baseline level.
"The mice that were exposed to antibiotics had the expression of indicator genes in their intestinal wall that were either too high or too low, but the transplant brought that back almost to the original levels and restored metabolic pathways," said another co-author. "We were able to identify groups of genes that returned to normal after the transplant as if the mice had never received the antibiotics."
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(21)00296-1
Replacing the new born babies microbiota to treat type I diabetes
- 1,477 views
- Added
Edited
Latest News
DNA attached to nanoparticl…
By newseditor
Posted 29 Mar
Neighboring synapses shape…
By newseditor
Posted 29 Mar
Complete vascularization of…
By newseditor
Posted 28 Mar
Immune cells identified as…
By newseditor
Posted 28 Mar
TB blood test which could d…
By newseditor
Posted 27 Mar
Other Top Stories
How a common virus triggers blood cancer
Read more
Monoclonal antibody against cancer mutant protein Ras developed!
Read more
How brain cancer spreads
Read more
How circadian 'clock' may influence cancer pathway
Read more
Cancer cells 'talk' to their environment, and it talks back
Read more
Protocols
Spatial proteomics in neuro…
By newseditor
Posted 28 Mar
All-optical presynaptic pla…
By newseditor
Posted 23 Mar
Epigenomic tomography for p…
By newseditor
Posted 20 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Publications
DNA corona on nanoparticles…
By newseditor
Posted 29 Mar
Co-dependent excitatory and…
By newseditor
Posted 29 Mar
A microfluidic platform int…
By newseditor
Posted 28 Mar
Salmonella manipulates macr…
By newseditor
Posted 28 Mar
BHLHE40/41 regulate microgl…
By newseditor
Posted 28 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar