Early-life exposure to the mineral manganese disrupts the way different areas of the brain involved in cognitive ability and motor control connect in teenagers, researchers report in a study published in PLOS ONE.
This study is the first to link evidence of metal exposure found in baby teeth to measures of brain connectivity. Researchers found links between early-life manganese exposure and altered functional connectivity of brain areas that support cognitive and motor control, potentially leading to low IQ, attention disorders, and hyperactivity.
"These findings could inform prevention and intervention efforts to reduce these poor outcomes in adolescents exposed to high levels of manganese," said the first author.
People can be exposed to manganese via air pollution, diet, drinking water, pesticides, and secondhand smoke. Researchers measured manganese concentrations in baby teeth to determine exposure during pregnancy, the first year of life, and early childhood.
They used functional magnetic resonance imaging (fMRI) scans to measure intrinsic functional connectivity of the brain in adolescents. Higher manganese concentrations in the first year of life were associated with increased intrinsic functional connectivity within cognitive control brain areas, but decreased connectivity between motor areas in adolescents.
Teen's exposure to manganese early could affect cognitive ability and motor control
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