Hypertension is a major risk factor of various diseases including stroke, heart failure, vascular disease, and kidney disease.
Angiotensin II, which is produced by the renin-angiotensin system, primarily functions as a physiological regulator of blood pressure and cardiovascular homeostasis, but it also plays a major role in the pathogenesis of hypertension. In the aorta, angiotensin II promotes hypertrophy of vascular smooth muscle cells through angiotensin type 1 receptor (AT1R), resulting in hypertension by increasing arterial wall thickness and vascular resistance. Additionally, angiotensin II induces physiological proliferation of neonatal but not adult vascular smooth muscle cells.
How vascular smooth muscle cells determine the responsiveness to angiotensin II under different developmental conditions is mostly unclear.
The research team found that the purinergic P2Y6 receptor (P2Y6R) promoted angiotensin II-induced hypertension in mice. Mice with a deletion of P2Y6R attenuated an angiotensin II-induced increase in blood pressure and medial hypertrophy.
AT1R and P2Y6R formed stable heterodimers. P2Y6R antagonist MRS2578 disrupted heterodimer formation of AT1R and P2Y6R, and suppressed angiotensin II-induced hypertension in mice.
Furthermore, P2Y6R abundance was developmentally increased in vascular smooth muscle cells. The increased abundance of P2Y6R converted AT1R-stimulated signaling in vascular smooth muscle cells from proliferation to hypertrophy.
These results suggest that increased formation of AT1R-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by angiotensin II.
http://stke.sciencemag.org/content/9/411/ra7
The age-related changes in receptor promotes hypertension
- 1,883 views
- Added
Edited
Latest News
Metabolic rewiring promotes…
By newseditor
Posted 18 Apr
A drug to prevent flu-induc…
By newseditor
Posted 18 Apr
New origin of deep brain waves
By newseditor
Posted 17 Apr
Starving cells hijack prote…
By newseditor
Posted 17 Apr
Miniature battery-free epid…
By newseditor
Posted 17 Apr
Other Top Stories
Removing brain cells linked to wakefulness and addiction may lessen…
Read more
Direct protein interaction triggers cell death!
Read more
Pathological differences in inherited versus sporadic Alzheimer's d…
Read more
How an ion channel regulates COPD
Read more
The brain pays attention to unfamiliar voices during sleep
Read more
Protocols
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Modular dual-color BiAD sen…
By newseditor
Posted 31 Mar
Publications
How does the microbiota con…
By newseditor
Posted 18 Apr
The integrated stress respo…
By newseditor
Posted 18 Apr
The immunobiology of herpes…
By newseditor
Posted 17 Apr
Circulating microbiome DNA…
By newseditor
Posted 17 Apr
Spindle oscillations in com…
By newseditor
Posted 17 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar