Sensory cells in the vagus nerve can detect and locate food in the esophagus. Their signals help transport the food onward to the stomach. Signal failure leads to swallowing disorders, say a research team. They have published their findings in “Neuron.”
Swallowing disorders can have many causes, and they occur more frequently in older people. But neurological diseases such as multiple sclerosis and Parkinson’s disease, and certain medications, can also prevent food moving normally from mouth to stomach. Possible consequences include malnutrition, weight loss, and dehydration.
Now a research team has investigated the process of swallowing in more detail. Writing in the journal “Neuron”, the researchers describe how sensory cells of the vagus nerve react to mechanical stimuli in the esophagus and trigger involuntary muscles movement, a process known as esophageal peristalsis. The vagus nerve, one of the 12 cranial nerves, provides information about the status of inner organs to the brain. The team’s study results could eventually lead to better treatments for swallowing disorders.
“Modern methods of single-cell sequencing made our work possible,” explains the senior author. “Using the sequencing data, we constructed genetic models that allowed us to study the functions of the sensory neurons in the vagal ganglia in more detail.” Ganglia are a group or “node” of neuronal bodies in the peripheral nervous system.
The scientists began by staining the neurons to see which organs they innervate. Then they determined whether and how they responded to mechanical stimuli in the esophagus. Lastly, they deactivated the cells to analyze how this affected swallowing. The researchers used video fluoroscopy to observe the swallowing in freely behaving, non-anesthetized mice in real time.
“When mice lost the neurons that provide information about mechanical stimuli in the esophagus, they lost the ability to reflexively perform the appropriate muscle movements that transport food to the stomach, and they quickly lost weight,” says the lead author. The weight loss, says the lead, shows that the neurons play a key role in bodily homeostasis.
“So, the esophagus isn’t just a tube that connects the mouth to the stomach,” the author says. “It uses mechanosensory feedback to fulfill its function.” The senior author adds that without these cells in the vagus nerve, food gets stuck in our esophagus. In some of the mice, it actually flowed back into the throat.
“Our work can now help develop better treatments for swallowing disorders. One option would be to pharmacologically activate the mechanoreceptors we identified,” says the senior author.
“These neurons probably play a crucial but as-yet unknown role in the development of certain respiratory diseases, or cardiovascular diseases such as hypertension,” the author says. Other researchers can also participate in these projects, as the team have developed a molecular atlas for all vagal neurons in mice. The atlas is freely available online.
The mechanisms behind swallowing
- 521 views