For centuries understanding how the order of events is stored in memory has been a mystery. However, researchers have worked out how the order of events in memory could be stored and later recalled in the hippocampal memory system in the brain.
The new research published in the journal 'Cell Reports' that an input region to the hippocampus - the lateral entorhinal cortex (LEC) - has time ramping cells that slowly change their rates of activity over hundreds of seconds; and on the discovery that hippocampal time cells fire at separate times in a sequence.
In the new research a theory and model was developed of how entorhinal time ramping cells produce hippocampal time cells which can be associated with places and people to help remember the sequence in which the people and places occurred during the remembered episode.
The theory demonstrates how we can remember what happened to us during the day in the correct order, and how we can provide an eye witness memory for a series of events.
The researchers show how the transformation of the code of the memory between the two brain areas - the LEC and the hippocampus - is achieved by a well-known type of neural network present in the brain, a competitive network.
The competitive network learns to allocate hippocampal neurons to respond to different combinations of the firing of the time ramping cells, and thus a temporal sequence can be formed.
The theory also accounts for the slow activity changes in time ramping cells by adaptation mechanisms, and shows how spontaneous memory recall can occur with the correct order of items in the memory.
Understanding the brain's memory and related mechanisms is helping not only to understand disorders of memory, but also is providing new approaches to understanding and treating mental disorders including depression and schizophrenia.
https://warwick.ac.uk/newsandevents/pressreleases/revealed_how_our
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30939-8
Latest News
Abusive drugs hijack natura…
By newseditor
Posted 23 Apr
Mechanism of action of the…
By newseditor
Posted 23 Apr
Role of fat in rare neurolo…
By newseditor
Posted 23 Apr
How protein synthesis in de…
By newseditor
Posted 22 Apr
Atlas of mRNA variants in d…
By newseditor
Posted 22 Apr
Other Top Stories
Human brains replay our waking experiences while we sleep
Read more
Genetic markers of type 2 diabetes in East Asians
Read more
Artificial Intelligence (AI) for cardiac diagnostics
Read more
3D imaging method to identify sperm cells moving at a high speed
Read more
How does the brain link events to form a memory?
Read more
Protocols
A programmable targeted pro…
By newseditor
Posted 23 Apr
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Publications
Exploiting pancreatic cance…
By newseditor
Posted 23 Apr
Structure of antiviral drug…
By newseditor
Posted 23 Apr
Type-I-interferon-responsiv…
By newseditor
Posted 23 Apr
Selenium, diabetes, and the…
By newseditor
Posted 23 Apr
Long-term neuropsychologica…
By newseditor
Posted 23 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar