Topically applied skin probiotic to treat acne

Acne on the face is often treated with topical antibiotics, which tend to be used for an extended period of time and contribute to the serious problem of antibiotic resistance. Scientists are investigating an alternative approach: using probiotics to alter the collection of bacteria and other microorganisms residing on the skin. Although the microbial ecosystem (or “microbiome”) on the skin may be perpetuate acne-causing inflammation, this ecosystem has proven difficult to alter.

Now the researchers have found a way to alter the skin microbiome and reduce inflammation using lactobacilli—a broad group of bacteria that are usually associated with the human gut and urogenital tract rather than the skin. In new research published in Cell Reports Medicine, the researchers show that specially-selected strains of lactobacilli both shift the skin microbiome in a positive manner and reduce acne lesions.

The senior researcher says, “Lactobacilli are well-documented safe and beneficial bacteria that produce lactic acid as a broad-acting antimicrobial molecule that can inhibit the growth and activity of a wide array of competing bacteria. They can also often reduce inflammation in different conditions. Therefore, we suspected they could work for this purpose even though they’re not highly abundant on the skin.”

The authors selected the three strains of lactobacilli—Lacticaseibacillus rhamnosus GG, L. plantarum WCFS1, and Lactiplantibacillus pentosus KCA1—using genome and functional screening to assess their robustness, safety and predicted immune system interactions. To make the bacteria suitable for topical application, they developed a cream with micro-capsules containing the microorganisms.

In both a pilot study and a randomized, placebo-controlled trial, the researchers asked people with mild-to-moderate acne to apply the cream on a daily basis. The intervention successfully reduced inflammatory lesions on subjects’ skin. It also modulated the cutaneous microbiome, in part by reducing the relative abundance of staphylococci, which are bacteria thought to perpetuate acne. Even after individuals discontinued application of the cream, the reduction in acne symptoms persisted for several weeks, leading the researchers to believe the trio of bacteria act, at least partially, by modulating the immune system. The author says more research is needed on the mode of action of these bacteria for the treatment of acne.