To identify genetic factors linked to defective trans infection, scientists searched for patterns in gene expression, or the degree to which specific genes are turned on or off, in APCs from eight HIV nonprogressors and eight progressors enrolled in MACS. Compared to APCs from progressors, cells from nonprogressors expressed higher levels of several cholesterol-related genes associated with defective trans infection.
These results improve understanding of how nonprogressors control HIV without drug therapy and potentially may contribute to new approaches to manage HIV infection.
http://www.niaid.nih.gov/news/newsreleases/2015/Pages/IAScholesterol.aspx
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