Damages to the central nervous system (CNS), for example in the case of spinal cord injury, can result in permanent loss of sensory and motor function. It is because the severed axons are unable to regenerate. As of today, there are very limited options to help these patients regain their motor abilities. Scientists have been exploring ways to enable the regeneration of severed axons, with a view to developing viable treatments in the long term.
In a study using mice, a research team untangled some of the complexities in the regeneration of severed axons. They found that the deletion of PTPN2, a phosphatase-coding gene, in neurons can prompt axons to regrow. When combined with the type II interferon IFNγ, it can further accelerate the process and boost the number of axons regenerated. The results have recently been published in the scientific journal Neuron.
The human nervous system is composed of two parts, namely the central and peripheral nervous systems. Unlike the central nervous system, peripheral nerves have stronger ability to regrow and repair by themselves after injury. Scientists have yet to fully understand the relationship between this self-repair and the intrinsic immune mechanism of the nervous system. Two mysteries the team wanted to resolve were how immune-related signaling pathways affected neurons after injury, and whether they could enhance axonal regeneration directly.
This study investigated whether the signaling pathway IFNγ-cGAS-STING had any role in the regeneration process of peripheral nerves. Researchers found that peripheral axons could directly modulate the immune response in their injured environment to promote self-repair after injury.
In previous research, the team had already demonstrated that elevating the neuronal activity and regulating the neuronal glycerolipid metabolism pathway could boost axon regenerative capacity. The current study is providing further insights into the search of treatment solutions for challenging conditions such as spinal cord injuries, with one possible option being the joining of several types of different signaling pathways.
https://www.cell.com/neuron/fulltext/S0896-6273(22)00961-8
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fdriving-axon&filter=22
Intrinsic immune mechanism in axon regeneration
- 737 views
- Added
Latest News
TB blood test which could d…
By newseditor
Posted 27 Mar
Propionate supplementation…
By newseditor
Posted 27 Mar
Role of human Kallistatin i…
By newseditor
Posted 26 Mar
Addressing both flu and COV…
By newseditor
Posted 26 Mar
How the brain senses body p…
By newseditor
Posted 26 Mar
Other Top Stories
Plasma treatment for strong adhesion without adhesives
Read more
"Scavenger" Molecule Prevents Nerve Agent Poisoning in Animals
Read more
Social interactions reduce feeding behavior!
Read more
Mosquitoes can hear up to 10 meters away
Read more
Brain's response to texture
Read more
Protocols
All-optical presynaptic pla…
By newseditor
Posted 23 Mar
Epigenomic tomography for p…
By newseditor
Posted 20 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Profiling native pulmonary…
By newseditor
Posted 08 Mar
Publications
Integrated plasma proteomic…
By newseditor
Posted 27 Mar
APP antisense oligonucleoti…
By newseditor
Posted 27 Mar
Targeting Erbin-mitochondri…
By newseditor
Posted 27 Mar
Regulation of Zbp1 by miR-9…
By newseditor
Posted 27 Mar
Pain-free oral delivery of…
By newseditor
Posted 27 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar