Researchers clarified the mechanism for inducing germinal-center B cells' differentiation into memory B cells, immune cells that remember antigens, at the molecular level.
When re-exposed to antigens such as bacteria or viruses, our bodies get rid of antigens by producing more antibodies than in the primary response. This is because memory B cells, which remember antigens in the primary immune response, are induced and respond faster in the secondary exposure to bacteria or viruses and differentiate into antibody-producing cells.
Vaccines block virus entry by making good use of such responses. When antigens such as viruses and vaccines enter the human body, germinal centers are produced within secondary lymph nodes and memory B cells are then induced from germinal-center B cells. However, the mechanism behind the induction was not yet understood, and the clarification of this mechanism has been an important research agenda.
A research clarified that germinal-center B cells with lower affinity maturation of antigens were easily differentiation-induced into memory B cells. The group also found that the expression level of transcription factor Bach2 in germinal-center B cells with lower affinity was significantly high, and that this high expression of Bach2 was important for memory B cell differentiation.
This group's achievement reverses the conventional wisdom that memory B cells are induced by high-affinity cells, possibly greatly influencing vaccine strategies targeting memory B cells. Bach2, an important gene for inducing memory B cells, may become an important target in vaccine strategies.
http://resou.osaka-u.ac.jp/en/research/2016/20160510_1
Mechanism for inducing memory B cell differentiation elucidated
- 3,011 views
- Added
Edited
Latest News
Metabolic rewiring promotes…
By newseditor
Posted 18 Apr
A drug to prevent flu-induc…
By newseditor
Posted 18 Apr
New origin of deep brain waves
By newseditor
Posted 17 Apr
Starving cells hijack prote…
By newseditor
Posted 17 Apr
Miniature battery-free epid…
By newseditor
Posted 17 Apr
Other Top Stories
How brain uses bodily signals to regulate fear
Read more
Separating fact from fiction for "anti-aging" diets
Read more
The link between vitamin D and inflammation
Read more
Chronic stress and depression related protein crystallized!
Read more
Thousands of novel brain-expressed gene isoforms identified!
Read more
Protocols
MemPrep, a new technology f…
By newseditor
Posted 08 Apr
A tangible method to assess…
By newseditor
Posted 08 Apr
Stem cell-derived vessels-o…
By newseditor
Posted 06 Apr
Single-cell biclustering fo…
By newseditor
Posted 01 Apr
Modular dual-color BiAD sen…
By newseditor
Posted 31 Mar
Publications
How does the microbiota con…
By newseditor
Posted 18 Apr
The integrated stress respo…
By newseditor
Posted 18 Apr
The immunobiology of herpes…
By newseditor
Posted 17 Apr
Circulating microbiome DNA…
By newseditor
Posted 17 Apr
Spindle oscillations in com…
By newseditor
Posted 17 Apr
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar