Immunotherapy research has shown that innate immune lymphocytes known as natural killer (NK) cells can recognize and destroy certain cancers, but NK cells often poorly infiltrate solid tumors, and many tumor-infiltrating NK cells exhibit signs of dysfunction.
Researchers report a genetically engineered mouse model of lung adenocarcinoma, in which the activity of endogenous NK cells within the tumor microenvironment (TME) was stimulated to fight established disease.
The model revealed that inducing the expression of activating ligands enhanced the ability of NK cells to proliferate, produce cytokines, and penetrate tumor tissue. Notably, the heightened activity did not appear to destroy tumor cells directly, but rather enhanced the ability of NK cells within the TME to recruit T cells, which can directly target tumor cells.
Though the findings are promising, the authors caution that the response was short-lived and additional studies are required to determine the underlying mechanisms.
According to the authors, the findings suggest that NK cells can be activated even in established disease to help boost antitumor immunity.
https://www.pnas.org/content/early/2019/08/12/1904253116
http://sciencemission.com/site/index.php?page=news&type=view&id=publications%2Fenhanced-adaptive&filter=22
Latest News
Brain hormone regulate both…
By newseditor
Posted 17 Mar
Blocking long non-coding RN…
By newseditor
Posted 17 Mar
Artificial intelligence and…
By newseditor
Posted 17 Mar
Blood-brain barrier protein…
By newseditor
Posted 17 Mar
Preventing heart attacks an…
By newseditor
Posted 17 Mar
Other Top Stories
Link between wakefulness and fight-or-flight response in mice
Read more
Treating pain without feeding addiction
Read more
Transfer of mitochondria from astrocytes to neurons after stroke
Read more
Leaky calcium triggers brainstem blackout that results in sudden ca…
Read more
Mitochondrial localization of a RNA binding protein is required for…
Read more
Protocols
Integration of Kupffer cell…
By newseditor
Posted 18 Mar
A mouse DRG genetic toolkit…
By newseditor
Posted 17 Mar
An optogenetic method for t…
By newseditor
Posted 13 Mar
Profiling native pulmonary…
By newseditor
Posted 08 Mar
Neuromuscular organoids mod…
By newseditor
Posted 06 Mar
Publications
Synaptopathy: presynaptic c…
By newseditor
Posted 18 Mar
Allergic Rhinitis
By newseditor
Posted 18 Mar
ALK upregulates POSTN and W…
By newseditor
Posted 18 Mar
PRODH safeguards human naiv…
By newseditor
Posted 18 Mar
Secretin-dependent signals…
By newseditor
Posted 17 Mar
Presentations
Hydrogels in Drug Delivery
By newseditor
Posted 12 Apr
Lipids
By newseditor
Posted 31 Dec
Cell biology of carbohydrat…
By newseditor
Posted 29 Nov
RNA interference (RNAi)
By newseditor
Posted 23 Oct
RNA structure and functions
By newseditor
Posted 19 Oct
Posters
A chemical biology/modular…
By newseditor
Posted 22 Aug
Single-molecule covalent ma…
By newseditor
Posted 04 Jul
ASCO-2020-HEALTH SERVICES R…
By newseditor
Posted 23 Mar
ASCO-2020-HEAD AND NECK CANCER
By newseditor
Posted 23 Mar
ASCO-2020-GENITOURINARY CAN…
By newseditor
Posted 23 Mar